Experimental validation of a rodent PET scanner prototype based on a single LYSO crystal tube.
Experimental validation of a rodent PET scanner prototype based on a single LYSO crystal tube.
复制标题
基于单LYSO晶体管的啮齿动物PET扫描仪原型的实验验证。
DOI：
10.1109/trpms.2021.3124448
复制
发表时间：
2022-07
影响因子：
4.4
通讯作者：
Gonzalez, Antonio J.
中科院分区：
文献类型：
--
作者：
Freire, Marta;Gonzalez-Montoro, Andrea;Canizares, Gabriel;Rezaei, Ahmadreza;Nuyts, Johan;Berr, Stuart S.;Williams, Mark B.;Benlloch, Jose M.;Gonzalez, Antonio J.
关键词：
提高小动物正电子发射断层成像仪器的灵敏度和空间分辨率是核成像研究的主要目标之一。这些参数由于探测器之间存在间隙而降低。本文通过实验验证了我们的无边缘临床前PET系统原型，该系统基于单个LYSO:Ce环，内径为62 mm， 10个外径为26 × 52 mm2。闪烁光通过8 × 8 sipm阵列耦合到面，使用行和列信号的投影读出读出。读数提供准确的交互深度（DOI）。我们已经实施了一种校准，减轻了轴向和轴向碰撞坐标的doi依赖性，以及能量光峰值增益。能量分辨率为23.4±1.8%。径向和轴向的平均空间分辨率分别为1.4±0.2和1.3±0.4 mm。我们发现系统中心的峰值灵敏度为3.8%，在0.27 mCi时最大NECR为40.6 kcps。利用阵列源的重构图像对图像质量进行了评价，并对NEMA图像质量模型进行了研究。
Improving sensitivity and spatial resolution in small animal Positron Emission Tomography imaging instrumentation constitutes one of the main goals of nuclear imaging research. These parameters are degraded by the presence of gaps between the detectors. The present manuscript experimentally validates our prototype of an edge-less pre-clinical PET system based on a single LYSO:Ce annulus with an inner diameter of 62 mm and 10 outer facets of 26 × 52 mm2. Scintillation light is read out by arrays of 8 × 8 SiPMs coupled to the facets, using a projection readout of the rows and columns signals. The readout provides accurate Depth of Interaction (DOI). We have implemented a calibration that mitigates the DOI-dependency of the transaxial and axial impact coordinates, and the energy photopeak gain. An energy resolution of 23.4 ± 1.8% was determined. Average spatial resolution of 1.4 ± 0.2 and 1.3 ± 0.4 mm FWHM were achieved for the radial and axial directions, respectively. We found a peak sensitivity of 3.8% at the system center, and a maximum NECR at 40.6 kcps for 0.27 mCi. The image quality was evaluated using reconstructed images of an array of sources and the NEMA image quality phantom was also studied.
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DOI：
10.1109/trpms.2018.2866899
发表时间：
2019-05-01
影响因子：
4.4
作者：
Gonzalez, Antonio J.;Gonzalez-Montoro, Andrea;Benlloch, Jose M.
通讯作者：
Benlloch, Jose M.
影响因子：
2.4
作者：
Stolin, Alexander V.;Martone, Peter F.;Raylman, Raymond R.
通讯作者：
Raylman, Raymond R.
影响因子：
3.5
作者：
Espana, Samuel;Marcinkowski, Radoslaw;Van Holen, Roel
通讯作者：
Van Holen, Roel
影响因子：
3.5
作者：
Vinke, Ruud;Levin, Craig S.
通讯作者：
Levin, Craig S.
影响因子：
3.9
作者：
Gonzalez, Antonio J.;Berr, Stuart S.;Benlloch, Jose M.
通讯作者：
Benlloch, Jose M.