Transcription-coupled mutagenesis by the DNA deaminase AID.

Transcription-coupled mutagenesis by the DNA deaminase AID.
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DOI:
10.1186/gb-2004-5-3-211
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发表时间:
2004
期刊:
影响因子:
12.3
通讯作者:
Maizels N
Maizels N
中科院分区:
生物学1区
文献类型:
--
作者:
Larson ED;Maizels N

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现在的证据表明,激活诱导脱氨酶(AID),这是参与开关重组和体细胞超突变,与RNA聚合酶II的旅行脱氨活性转录的DNA。活化诱导的脱氨酶(AID)启动活化B细胞中免疫球蛋白基因的开关重组和体细胞超突变。现在有令人信服的证据表明,AID与RNA聚合酶II一起旅行,以脱氨活性转录的DNA。
Evidence now shows that activation-induced deaminase (AID), wich is involved in switch recombination and somatic hypermutation, travels with RNA polymerase II to deaminate actively transcribed DNA. Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. Compelling evidence now shows that AID travels with RNA polymerase II to deaminate actively transcribed DNA.
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