Assessment of colonic transit time using MRI: a feasibility study
Assessment of colonic transit time using MRI: a feasibility study
复制标题
使用 MRI 评估结肠传输时间：可行性研究
作者：
S. Buhmann;C. Kirchhoff;R. Ladurner;T. Mussack;M. Reiser;A. Lienemann
这项先导性研究的目的是评估一种新的非侵入性检查方法，该方法使用MRI来定量口服Gd-生理盐水胶囊后的结肠通过时间。研究对象为既往无胃肠道疾病或急性胃肠道疾病症状的健康志愿者。在为期3天的标准化胃肠内容物饮食后，志愿者吞下了5粒Gd-DTPA/生理盐水胶囊。将7种不同浓度的Gd-DTPA/生理盐水溶液按1：0~0：1的比例进行稀释试验。在摄入胶囊后，使用1.5Tesla系统在0h、3h、6h、12h、24h、36h和60h获得了冠状Flash T1和True FISP序列。序列由两个独立的专家分析以定位胶囊。对男女患者的总体结肠通过时间进行了单独分析。健康志愿者15例，女性7例，男性8例，平均年龄(34±13)岁。模体研究在T1和T2加权序列中提供了最佳对比度，定义了Gd-DTPA/生理盐水0.9%溶液的比率为1：10。女性平均通过时间为41±9小时，男性为31±10小时。MRI是评估结肠通过时间的一种合适的方法，具有不受辐射照射、检查时间短、可动态评估结肠通过时间以及将来可用于临床常规的优点。
The aim of this pilot study was to evaluate a new, non-invasive examination method using MRI for the quantification of the colonic transit time after oral administration of gadolinium-saline solution filled capsules. Healthy volunteers without previous or acute symptoms of gastrointestinal disorders were enrolled. After a 3-day diet for the standardization of gastrocolonic content the volunteers swallowed five Gd-DTPA/saline 0.9%-filledcapsules. Seven different concentrations of Gd-DTPA/saline 0.9% solution between 1:0 and 0:1 were tested in a dilution series. Following ingestion of capsules, coronal Flash T1 and True Fisp sequences using a 1.5 Tesla system were obtained at 0 h, 3 h, 6 h, 12 h, 24 h, 36 h and 60 h. Sequences were analyzed by two independent experts for locating the capsules. Overall colonic transit time was separately analyzed for both genders. Fifteen healthy volunteers (7 females, 8 males; mean age 34±13 years) were enrolled. The phantom study provided the best contrast in both the T1-and T2-weighted sequences defining a ratio of 1:10 for Gd-DTPA/saline 0.9% solution. The mean transit time accounted for 41±9 h in women and for 31±10 h in men. MRI is an adequate method for the assessment of colonic transit time offering the advantages of no exposure to radiation, short examination time, possible dynamic evaluation of the transit and the practicability in terms of a future adoption to clinical routine.
影响因子：
29.4
作者：
Metcalf, Amanda M.;Phillips, Sidney F.;Wolff, Bruce G.
通讯作者：
Wolff, Bruce G.
影响因子：
29.4
作者：
Krevsky,B;Malmud,LS;D'Ercole,F;Maurer,AH;Fisher,RS
通讯作者：
Fisher,RS