Impact of Helicobacter pylori colonization density and depth on gastritis severity.
Impact of Helicobacter pylori colonization density and depth on gastritis severity.
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DOI：
10.1186/s12941-024-00666-7
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发表时间：
2024-01-12
影响因子：
5.7
通讯作者：
Xie, Yong
中科院分区：
文献类型：
--
作者：
Peng, Jianxiang;Xie, Jinliang;Liu, Dingwei;Yang, Kaijie;Wu, Shuang;Liu, Dongsheng;Huang, Deqiang;Xie, Yong
幽门螺杆菌（H. pylori）感染是慢性胃病最常见的病因。 H. pylori胃炎会逐渐演变为胃萎缩、肠化生、不典型增生和恶性病变。在此，本研究旨在探讨幽门螺杆菌定植密度和深度对胃炎组织学参数严重程度的潜在影响。 2019年12月至2022年7月进行了一项前瞻性单中心研究，招募通过组织病理学评估确诊为慢性幽门螺杆菌感染的患者。免疫组化染色检测H. pylori定植状况，苏木精-伊红染色检测胃标本病理变化。收集流行病学、内窥镜和组织病理学数据。共有 1120 名患者参与，平均年龄为 45.8 岁。无论既往有H. pylori根除治疗史，H. pylori定植密度和深度与胃炎活动强度之间均观察到显着相关性（均P<0.05）。幽门螺杆菌定植密度和深度水平最低的患者表现出最高水平的轻度活动。在整个参与者和反H.在未接受过幽门螺杆菌治疗的参与者中，幽门螺杆菌定植密度和深度与慢性胃炎和胃萎缩的严重程度显着相关（均P<0.05）。幽门螺杆菌定植密度（P = 0.001）和深度（P = 0.047）与未接受任何抗幽门螺杆菌治疗的患者溃疡形成显着相关。幽门螺杆菌治疗。幽门螺杆菌定植的密度和深度与其他组织病理学发现（包括淋巴结肿大、淋巴滤泡形成和发育不良）之间没有观察到显着关联。随着幽门螺杆菌定植密度和深度的增加，胃炎的活动性和严重程度也随之增加，溃疡形成的风险也随之增加。在线版本包含可在 10.1186/s12941-024-00666-7 获取的补充材料。
Helicobacter pylori (H. pylori) infection is the most common etiology of chronic gastric. H. pylori gastritis would gradually evolve into gastric atrophy, intestinal metaplasia, dysplasia and malignant lesions. Herein, this study aimed to investigate the potential impact of H. pylori colonization density and depth on the severity of histological parameters of gastritis. A prospective monocentric study was conducted from December 2019 to July 2022, enrolling patients with confirmed chronic H. pylori infection via histopathological evaluation. H. pylori colonization status was detected by immunohistochemical staining, pathological changes of gastric specimens were detected by hematoxylin eosin staining. Epidemiological, endoscopic and histopathological data were collected. A total of 1120 patients with a mean age of 45.8 years were included. Regardless of the previous history of H. pylori eradication treatment, significant correlations were observed between the density and depth of H. pylori colonization and the intensity of gastritis activity (all P < 0.05). Patients with the lowest level of H. pylori colonization density and depth exhibited the highest level of mild activity. In whole participants and anti-H. pylori treatment-naive participants, H. pylori colonization density and depth were markedly correlated with the severity of chronic gastritis and gastric atrophy (all P < 0.05). H. pylori colonization density (P = 0.001) and depth (P = 0.047) were significantly associated with ulcer formation in patients naive to any anti-H. pylori treatment. No significant associations were observed between the density and depth of H. pylori colonization and other histopathological findings including lymphadenia, lymphoid follicle formation and dysplasia. As the density and depth of H. pylori colonization increased, so did the activity and severity of gastritis, along with an elevated risk of ulcer formation. The online version contains supplementary material available at 10.1186/s12941-024-00666-7.
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