Heme and HO-1 Inhibition of HCV, HBV, and HIV.
Heme and HO-1 Inhibition of HCV, HBV, and HIV.
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DOI：
10.3389/fphar.2012.00129
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发表时间：
2012
影响因子：
5.6
通讯作者：
Zhu Z
中科院分区：
文献类型：
--
作者：
Schmidt WN;Mathahs MM;Zhu Z
丙型肝炎病毒、人类免疫缺陷病毒和B型肝炎病毒是慢性病毒感染，在全世界引起相当大的发病率和死亡率。在这些病毒的鉴定和测序之后的几十年中，体外实验证明血红素加氧酶-1、其氧化产物和血红素加氧酶系统的相关化合物抑制所有3种病毒的复制。这篇综述的目的是批判性地评价和总结描述和表征这种显着行为的开创性研究。它还将讨论更多的最近的工作，发现这些独特的抗病毒剂的抗病毒机制和靶点。尽管这些病毒是不同的病原体，在结构和生命周期上有很大的差异，但重要的是血红素和相关化合物在所有三个物种的病毒靶位点上显示出惊人的相似性。总的来说，这些发现强烈表明，我们应该向前迈进，将血红素和相关的四吡咯开发成多功能的抗病毒药物，可用于治疗单一或多种病毒感染的患者。
Hepatitis C virus, human immunodeficiency virus, and hepatitis B virus are chronic viral infections that cause considerable morbidity and mortality throughout the world. In the decades following the identification and sequencing of these viruses, in vitro experiments demonstrated that heme oxygenase-1, its oxidative products, and related compounds of the heme oxygenase system inhibit replication of all 3 viruses. The purpose of this review is to critically evaluate and summarize the seminal studies that described and characterized this remarkable behavior. It will also discuss more recent work that discovered the antiviral mechanisms and target sites of these unique antiviral agents. In spite of the fact that these viruses are diverse pathogens with quite profound differences in structure and life cycle, it is significant that heme and related compounds show striking similarity for viral target sites across all three species. Collectively, these findings strongly indicate that we should move forward and develop heme and related tetrapyrroles into versatile antiviral agents that could be used therapeutically in patients with single or multiple viral infections.
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