Multi-country estimate of different manifestations of aspergillosis in cystic fibrosis.
Multi-country estimate of different manifestations of aspergillosis in cystic fibrosis.
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对囊性纤维化中曲霉菌病不同表现的多国评估。
DOI：
10.1371/journal.pone.0098502
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Denning DW
中科院分区：
文献类型：
--
作者：
Armstead J;Morris J;Denning DW
曲霉属可导致CF中的过敏性支气管肺曲霉病（ABPA）、曲霉菌致敏和曲霉菌支气管炎。这些实体的相对频率最近已被确定在一个大型的英国成人CF队列。我们使用这些数据来估计30个报告CF的国家中成人CF患者的曲霉病和ABPA病例负担。访问国家和国际CF登记数据，并评估其完整性和年龄分布。已发表的CF中ABPA（17.7%）、曲霉菌致敏（14.6%）和曲霉菌支气管炎（30%）的比例适用于>18岁的患者，并与已报告的ABPA病例进行比较。在全球估计的76，201例CF患者中（不包括印度），37，714例年龄>18岁。成人与儿童的比例从挪威的63%到巴西的20%不等。成人ABPA病例预计为6，675例，其中目前仅记录了2，221例（33%），表明诊断严重不足。ABPA诊断率与估计率相比因国家而异，从101%（法国）到14.5%（希腊），尽管与英国相比，遗传变异可能是真正的差异。目前在CF登记研究中未识别或记录曲霉菌性支气管炎，但预计有10，988例成人病例。与支气管扩张增加和FEV1降低相关的曲霉菌致敏影响了预期的5，506例无ABPA或曲霉菌支气管炎的患者。ABPA和曲霉菌支气管炎估计共同影响17，989名成年人，占成年CF人口的47.7%。ABPA也发生在儿童和青少年中，登记处记录了984例病例。ECFS登记研究、美国、英国、爱尔兰、比利时和荷兰按年龄列出的ABPA诊断率可用。4岁以下儿童的发病率<1%，在整个儿童期和青少年期发病率不断上升，各国之间存在显著差异。新发表的诊断标准和方法应有助于更好地认识曲菌病的CF，使更好的CF疾病控制。
Aspergillus spp. can lead to allergic bronchopulmonary aspergillosis (ABPA), Aspergillus sensitisation and Aspergillus bronchitis in CF. The relative frequencies of these entities have recently been ascertained in a large UK adult CF cohort. We have used this data to estimate the burden of aspergillosis and ABPA cases in adult CF patients in 30 countries reporting CF. National and international CF registry data was accessed and assessed for completeness and age distribution. Published proportions of ABPA (17.7%), Aspergillus sensitisation (14.6%) and Aspergillus bronchitis (30%) in CF were applied to those >18 years and compared with notified ABPA cases. Of the 76,201 estimated CF patients worldwide (not including India), 37,714 were >18 years. The proportion of adults to children varied from 63% in Norway to 20% in Brazil. ABPA caseload in adults is anticipated to be 6,675 cases of which only 2,221 cases (33%) are currently recorded, indicating substantial underdiagnosis. The ABPA diagnosis rate compared with estimated rates varies by country from 101% (France) to 14.5% (Greece), although genetic variation could account for genuine differences compared with the UK. Aspergillus bronchitis is not currently recognised or recorded in CF registries but there are an anticipated 10,988 adult cases. Aspergillus sensitisation, associated with increased bronchiectasis and reduced FEV1, affects an anticipated 5,506 patients without ABPA or Aspergillus bronchitis. Together ABPA and Aspergillus bronchitis are estimated to affect 17,989 adults, 47.7% of the adult CF population. ABPA also occurs in children and teenagers and 984 cases were documented in registries. Diagnosed ABPA rates by age were available for the ECFS registry, USA, UK, Ireland, Belgium and Netherlands. The rate was <1% under 4 years, and increased throughout childhood and adolescence, with marked variation between countries. Newly published diagnostic criteria and methods should facilitate better recognition of aspergillosis in CF, allowing better CF disease control.
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影响因子：
6.1
作者：
Agarwal, R.;Chakrabarti, A.;Denning, D. W.
通讯作者：
Denning, D. W.
DOI：
10.1007/978-90-481-2408-4_39
发表时间：
2010-01-01
期刊：
ASPERGILLOSIS: FROM DIAGNOSIS TO PREVENTION
影响因子：
--
作者：
Agarwal, Ritesh;Chakrabarti, Arunaloke
通讯作者：
Chakrabarti, Arunaloke
影响因子：
--
作者：
Fillaux, Judith;Bremont, Francois;Magnaval, Jean-Francois
通讯作者：
Magnaval, Jean-Francois
影响因子：
9.6
作者：
Agarwal, Ritesh;Gupta, Dheeraj;Jindal, Surinder K.
通讯作者：
Jindal, Surinder K.
影响因子：
2.9
作者：
Denning, David W.;Pleuvry, Alex;Cole, Donald C.
通讯作者：
Cole, Donald C.