Current progress in Reactive Oxygen Species (ROS)-Responsive materials for biomedical applications.
Current progress in Reactive Oxygen Species (ROS)-Responsive materials for biomedical applications.
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DOI：
10.1002/adhm.201200423
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发表时间：
2013
影响因子：
10
通讯作者：
Sung, Hak-Joon
中科院分区：
文献类型：
--
作者：
Lee, Sue Hyun;Gupta, Mukesh K.;Bang, Jae Beum;Bae, Hojae;Sung, Hak-Joon
近年来，“刺激敏感”生物材料作为一种新的治疗方法，在与动态生理条件相互作用方面取得了重大进展。活性氧（ROS）的产生与重要的病理生理事件有关，如动脉粥样硬化、衰老和癌症。ROS通常在病变细胞和组织中局部过量产生，并且它们单独且同步地导致与局部发病机制相关的许多异常。因此，开发ROS响应性材料的优点超出了治疗递送的位点特异性靶向，并且可能包括通过材料性质的程序化变化来导航、感测和修复细胞损伤。本文综述了活性氧诱导溶解度转换或降解的生物材料的机制和发展，以及它们的性能和未来生物医学应用的潜力。
Recently, significant progress has been made in developing “stimuli-sensitive” biomaterials as a new therapeutic approach to interact with dynamic physiological conditions. Reactive oxygen species (ROS) production has been implicated in important pathophysiological events, such as atherosclerosis, aging, and cancer. ROS are often overproduced locally in diseased cells and tissues, and they individually and synchronously contribute to many of the abnormalities associated with local pathogenesis. Therefore, the advantages of developing ROS-responsive materials extend beyond site-specific targeting of therapeutic delivery, and potentially include navigating, sensing, and repairing the cellular damages via programmed changes in material properties. Here we review the mechanism and development of biomaterials with ROS-induced solubility switch or degradation, as well as their performance and potential for future biomedical applications.
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影响因子：
3.9
作者：
Anglin, EJ;Schwartz, MP;Sailor, MJ
通讯作者：
Sailor, MJ
DOI：
10.1016/j.jconrel.2012.07.042
发表时间：
2012-09-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Gupta MK;Meyer TA;Nelson CE;Duvall CL
通讯作者：
Duvall CL
影响因子：
64.8
作者：
Houstis, N;Rosen, ED;Lander, ES
通讯作者：
Lander, ES
影响因子：
3.6
作者：
AITKEN, RJ;CLARKSON, JS;FISHEL, S
通讯作者：
FISHEL, S
影响因子：
10.8
作者：
Cammas, S;Suzuki, K;Okano, T
通讯作者：
Okano, T