Neuroendocrine control of the transition to reproductive senescence: lessons learned from the female rodent model.
Neuroendocrine control of the transition to reproductive senescence: lessons learned from the female rodent model.
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DOI：
10.1159/000335994
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发表时间：
2012
影响因子：
4.1
通讯作者：
Gore AC
中科院分区：
文献类型：
--
作者：
Kermath BA;Gore AC
向生殖衰老的自然过渡是随着衰老而发生的重要生理过程，导致女性更年期以及大多数哺乳动物物种的生育能力下降或丧失。本综述重点关注啮齿动物模型如何让我们了解 GnRH 神经分泌功能与年龄相关的变化以及随后的生殖能力丧失。对大鼠和小鼠的研究显示 GnRH 细胞的分子、形态和功能发生变化。此外，在生殖衰老过程中，性类固醇对下丘脑的反馈改变，导致刺激信号的减少和 GnRH 神经元的抑制音调的增加。在肽释放到门脉系统的 GnRH 末端部位，正中隆起的细胞结构随着衰老而变得混乱，神经胶质 - GnRH 神经元通讯的机制可能被破坏。这些变化可能导致 GnRH 分泌失调并导致生殖能力下降。有趣的是，生殖衰老对 GnRH 回路的影响在中年甚至在任何明显的周期性生理变化之前就可以观察到。我们推测下丘脑可能在这一中年转变中发挥关键作用。由于这些衰老过程存在显着的物种差异，我们还将啮齿类动物的衰老与灵长类动物的衰老进行了比较和对比。本文讨论的工作表明，为了了解生殖衰老的神经内分泌机制，需要在卵巢完整模型中进行进一步的研究。
The natural transition to reproductive senescence is an important physiological process that occurs with aging, resulting in menopause in women and diminished or lost fertility in most mammalian species. This review focuses on how rodent models have informed our knowledge of age-related changes in GnRH neurosecretory function and the subsequent loss of reproductive capacity. Studies in rats and mice have shown molecular, morphological and functional changes in GnRH cells. Furthermore, during reproductive aging altered sex steroid feedback to the hypothalamus contributes to a decrease of stimulatory signaling and increase in inhibitory tone onto GnRH neurons. At the site of the GnRH terminals where the peptide is released into the portal vasculature, the cytoarchitecture of the median eminence becomes disorganized with aging, and mechanisms of glial-GnRH neuronal communication may be disrupted. These changes can result in the dysregulation of GnRH secretion with reproductive decline. Interestingly, reproductive aging effects on the GnRH circuitry are observed in middle age even prior to any obvious physiological changes in cyclicity. We speculate that the hypothalamus may play a critical role in this mid-life transition. Because there are substantial species differences in these aging processes, we also compare and contrast rodent aging to that in primates. Work discussed herein shows that in order to understand neuroendocrine mechanisms of reproductive senescence, further research needs to be conducted in ovarian-intact models.
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影响因子：
4.5
作者：
Boettner, M.;Leonhardt, S.;Jarry, H.
通讯作者：
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影响因子：
4.8
作者：
de Seranno, Sandrine;de Tassigny, Xavier d'Anglemont;Prevot, Vincent
通讯作者：
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DOI：
10.1073/pnas.1834399100
发表时间：
2003-09-16
影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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Rocca, WA