Focused beam dosimetry of short VHEE bunches

Focused beam dosimetry of short VHEE bunches
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短 VHEE 束的聚焦束剂量测定

DOI:
10.1117/12.2595299
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发表时间:
2021
期刊:
--
影响因子:
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通讯作者:
Brunetti E
Brunetti E
中科院分区:
--
文献类型:
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作者:
Brunetti E

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由10s tw级激光驱动的加速器可以产生飞秒级持续时间和100兆电子伏特能量的电子束。这种短束的一个潜在应用是高剂量率放疗,如果单次注射足够大的剂量,它可以过渡到FLASH放疗。本文采用蒙特卡罗模拟方法研究了电子束在水模体中的束长演化。我们发现,在准直和弱聚焦的几何结构中,当电子能量超过100 MeV时,束与30厘米长的水影相互作用后,束的持续时间延长到1-10 ps。相应的剂量率约为200 Gy/s /个初级电子,远高于传统放射治疗。
Accelerators driven by 10s TW-class lasers can produce electron bunches with femtosecond-scale duration and energy of 100s of MeV. A potential application of such short bunches is high-dose rate radiotherapy, which could transition to FLASH radiotherapy if a sufficiently large dose is delivered in a single shot. Here we present Monte Carlo simulations to study the bunch length evolution of an electron beam propagating in a water phantom. We show that for electron energies above 100 MeV the bunch lengthens to 1–10 ps duration after interaction with a 30 cm long water phantom, both for a collimated and weakly focused geometry. The corresponding dose rates are on the order of 200 Gy/s per primary electron, much higher than in conventional radiotherapy.
DOI: 10.1016/j.clon.2019.04.001
发表时间: 2019-07-01
期刊: CLINICAL ONCOLOGY
影响因子: 3.4
作者:
Vozenin, M-C;Hendry, J. H.;Limoli, C. L.
通讯作者: Limoli, C. L.
DOI: 10.1038/nature02939
发表时间: 2004-09-30
期刊: NATURE
影响因子: 64.8
作者:
Mangles, SPD;Murphy, CD;Krushelnick, K
通讯作者: Krushelnick, K
DOI: 10.1038/nature02963
发表时间: 2004-09-30
期刊: NATURE
影响因子: 64.8
作者:
Faure, J;Glinec, Y;Malka, V
通讯作者: Malka, V