Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction.
Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction.
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DOI：
10.1038/s41536-021-00186-4
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发表时间：
2021-11-17
影响因子：
7.2
通讯作者：
Abdel-Latif A
中科院分区：
文献类型：
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作者：
Peng H;Shindo K;Donahue RR;Gao E;Ahern BM;Levitan BM;Tripathi H;Powell D;Noor A;Elmore GA;Satin J;Seifert AW;Abdel-Latif A
复杂的组织再生在成年哺乳动物中极为罕见。然而，一个例外是多刺小鼠（Acomys）的多个器官的上级组织愈合。虽然Acomys物种表现出以最小的瘢痕愈合复杂组织的显着能力，但对其心脏结构和对心脏损伤的反应知之甚少。在这项研究中，我们首先检查了基线Acomys心脏解剖结构和功能，与常用的近交和远交实验室小鼠品系（C57BL6和CFW）进行比较。虽然我们的结果表明Acomys和Mus之间的心脏解剖结构和功能相当，但Acomys表现出更高百分比的心肌细胞，显示出不同的特征。对于心肌梗死，所有动物的初始心脏损伤水平相当。然而，Acomys表现出对损伤的上级缺血耐受性和细胞保护作用，如与近交系和远交系小鼠品系相比，损伤后50天心脏功能稳定、存活率较高和瘢痕尺寸较小所证明的。这种现象与梗死周围和梗死区域的内皮细胞增殖增强、血管生成增加和中等血管成熟相关。总体而言，这些研究结果表明，心肌梗死后多刺小鼠心肌保护增强，并建立Acomys作为一种新的成年哺乳动物模型的心脏研究。
Complex tissue regeneration is extremely rare among adult mammals. An exception, however, is the superior tissue healing of multiple organs in spiny mice (Acomys). While Acomys species exhibit the remarkable ability to heal complex tissue with minimal scarring, little is known about their cardiac structure and response to cardiac injury. In this study, we first examined baseline Acomys cardiac anatomy and function in comparison with commonly used inbred and outbred laboratory Mus strains (C57BL6 and CFW). While our results demonstrated comparable cardiac anatomy and function between Acomys and Mus, Acomys exhibited a higher percentage of cardiomyocytes displaying distinct characteristics. In response to myocardial infarction, all animals experienced a comparable level of initial cardiac damage. However, Acomys demonstrated superior ischemic tolerance and cytoprotection in response to injury as evidenced by cardiac functional stabilization, higher survival rate, and smaller scar size 50 days after injury compared to the inbred and outbred mouse strains. This phenomenon correlated with enhanced endothelial cell proliferation, increased angiogenesis, and medium vessel maturation in the peri-infarct and infarct regions. Overall, these findings demonstrate augmented myocardial preservation in spiny mice post-MI and establish Acomys as a new adult mammalian model for cardiac research.
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DOI：
10.1177/1074248411405990
发表时间：
2011-09-01
影响因子：
2.6
作者：
Kloner, Robert A.
通讯作者：
Kloner, Robert A.
影响因子：
64.5
作者：
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通讯作者：
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影响因子：
64.8
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影响因子：
64.8
作者：
Carmeliet, Peter;Jain, Rakesh K.
通讯作者：
Jain, Rakesh K.
影响因子：
64.8
作者：
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