Sympathetic alternans. Evidence for arterial baroreflex control of muscle sympathetic nerve activity in congestive heart failure.
Sympathetic alternans. Evidence for arterial baroreflex control of muscle sympathetic nerve activity in congestive heart failure.
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同情交替。
DOI：
10.1161/01.cir.95.2.316
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发表时间：
1997
期刊：
影响因子：
37.8
通讯作者：
J. Floras
中科院分区：
文献类型：
--
作者：
Shin;H. Dajani;B. L. Senn;G. Newton;J. Floras
记录了3例严重心力衰竭患者肌交感神经活动(MSNA)波幅的改变。在有交替脉搏的指标性患者中，MSNA的波幅与先前舒张压的变化呈负相关，滞后时间为1.2~1.3秒，表明脉搏波幅的振荡主要由这一血压分量的变化决定。对血压和MSNA信号的频谱分析确定了两个频谱峰值，一个位于心脏频率，另一个峰值在交替频率(即，心率的一半)处具有更大的频谱功率。当硝酸甘油消除交链孢子时，血压和MSNA的后一个峰值消失。交感神经交感交感神经传导通路与交感神经交感神经传导通路的同步存在，以及舒张压传入信号的变化与交感神经流出的波幅之间的快速转换，提示在心力衰竭时，MSNA对动脉压力感受性反射的控制必须是主动的和快速反应的。
Alternation in the amplitude of muscle sympathetic nerve activity (MSNA) was documented in three patients with severe heart failure. In the index patient with pulsus alternans, the amplitude of MSNA was inversely related to changes in the preceding diastolic pressure with a lag time of 1.2 to 1.3 seconds, indicating that oscillations in burst amplitude are determined primarily by changes in this component of blood pressure. Spectral analysis of the blood pressure and MSNA signals identified two spectral peaks, one at the cardiac frequency and a second peak, with greater spectral power, at the alternans frequency (ie, at half the heart rate). The latter peak for both blood pressure and MSNA disappeared when alternans was abolished by nitroglycerin. The presence of sympathetic alternans in synchrony with pulsus alternans and the rapid transduction of changes in the diastolic blood pressure afferent signal to the amplitude of sympathetic outflow indicate that the arterial baroreflex control of MSNA must be active and rapidly responsive in human heart failure.
舒张压决定人类对压力扰动的自主反应。
DOI：
10.1152/jappl.1989.66.2.800
发表时间：
1989
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Sanders,JS;Ferguson,DW
通讯作者：
Ferguson,DW
影响因子：
37.8
作者：
LEIMBACH, WN;WALLIN, BG;MARK, AL
通讯作者：
MARK, AL