Cognitive Training Using a Novel Memory Game on an iPad in Patients with Amnestic Mild Cognitive Impairment (aMCI).
Cognitive Training Using a Novel Memory Game on an iPad in Patients with Amnestic Mild Cognitive Impairment (aMCI).
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在iPad上使用新颖的记忆游戏进行认知训练，患有柔和的轻度认知障碍患者（AMCI）。
DOI：
10.1093/ijnp/pyx040
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发表时间：
2017-08-01
期刊：
影响因子：
--
通讯作者：
Sahakian BJ
中科院分区：
文献类型：
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作者：
Savulich G;Piercy T;Fox C;Suckling J;Rowe JB;O'Brien JT;Sahakian BJ
认知训练对轻度认知障碍患者有效，但通常不能解决与记忆困难的老年人群相关的动机缺陷。我们在42名诊断为遗忘型轻度认知障碍的患者中进行了一项使用iPad上的新型记忆游戏进行认知训练的随机对照试验，这些患者被分配到认知训练组（n=21; 4周内玩8小时游戏）或对照组（n=21;照常就诊）。在剑桥神经心理测试自动电池配对联想学习任务中，发现认知表现在错误数量和所需试验次数方面存在显著的时间-模式-小组相互作用（P= 0.044; P= 0.027）。在剑桥神经心理学测试自动成套配对联想学习第一次试验记忆评分（P= 0.002）、简易精神状态检查（P= 0.036）、简明视觉空间记忆测试（P= 0.032）和冷漠评价量表（P= 0.026）中也发现了显著的时间-组相互作用。组内比较显示，认知训练对情景记忆有高度特异性的影响。认知训练组在每玩一个小时的游戏后都保持着高水平的享受和动力，随着时间的推移，自信心和自我评价的记忆能力不断提高。在认知训练组中，情景记忆得到了有力的改善。“游戏化”认知训练也可以增强遗忘型轻度认知障碍患者的视觉空间能力。游戏化通过增加动机来最大限度地参与认知训练，并可以补充遗忘型轻度认知障碍和轻度阿尔茨海默病的药物治疗。需要更大规模的对照试验来复制和扩展这些发现。
Cognitive training is effective in patients with mild cognitive impairment but does not typically address the motivational deficits associated with older populations with memory difficulties. We conducted a randomized controlled trial of cognitive training using a novel memory game on an iPad in 42 patients with a diagnosis of amnestic mild cognitive impairment assigned to either the cognitive training (n=21; 8 hours of gameplay over 4 weeks) or control (n=21; clinic visits as usual) groups. Significant time-by-pattern-by-group interactions were found for cognitive performance in terms of the number of errors made and trials needed on the Cambridge Neuropsychological Test Automated Battery Paired Associates Learning task (P=.044; P=.027). Significant time-by-group interactions were also found for the Cambridge Neuropsychological Test Automated Battery Paired Associates Learning first trial memory score (P=.002), Mini-Mental State Examination (P=.036), the Brief Visuospatial Memory Test (P=.032), and the Apathy Evaluation Scale (P=.026). Within-group comparisons revealed highly specific effects of cognitive training on episodic memory. The cognitive training group maintained high levels of enjoyment and motivation to continue after each hour of gameplay, with self-confidence and self-rated memory ability improving over time. Episodic memory robustly improved in the cognitive training group. “Gamified” cognitive training may also enhance visuospatial abilities in patients with amnestic mild cognitive impairment. Gamification maximizes engagement with cognitive training by increasing motivation and could complement pharmacological treatments for amnestic mild cognitive impairment and mild Alzheimer’s disease. Larger, more controlled trials are needed to replicate and extend these findings.
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影响因子：
168.9
作者：
Moher, D;Schulz, KF;Altman, DG
通讯作者：
Altman, DG
影响因子：
64.8
作者：
Collins, Pamela Y.;Patel, Vikram;Joestl, Sarah S.;March, Dana;Insel, Thomas R.;Daar, Abdallah S.
通讯作者：
Daar, Abdallah S.
影响因子：
2.6
作者：
Dickerson, Bradford C.;Sperling, Reisa A.
通讯作者：
Sperling, Reisa A.
影响因子：
3.5
作者：
EAGGER, SA;LEVY, R;SAHAKIAN, BJ
通讯作者：
SAHAKIAN, BJ
DOI：
10.1007/7854_2015_5001
发表时间：
2016-01-01
期刊：
TRANSLATIONAL NEUROPSYCHOPHARMACOLOGY
影响因子：
--
作者：
Barnett, Jennifer H.;Blackwell, Andrew D.;Robbins, Trevor W.
通讯作者：
Robbins, Trevor W.