Autophagy in HCV Replication and Protein Trafficking.
Autophagy in HCV Replication and Protein Trafficking.
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DOI：
10.3390/ijms22031089
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发表时间：
2021-01-22
影响因子：
5.6
通讯作者：
Ou JJ
中科院分区：
文献类型：
--
作者：
Chu JYK;Ou JJ
Autophagy is a catabolic process that is important for maintaining cellular homeostasis. It is also known to possess other functions including protein trafficking and anti-microbial activities. Hepatitis C virus (HCV) is known to co-opt cellular autophagy pathway to promote its own replication. HCV regulates autophagy through multiple mechanisms to control intracellular protein and membrane trafficking to enhance its replication and suppress host innate immune response. In this review, we discuss the current knowledge on the interplay between HCV and autophagy and the crosstalk between HCV-induced autophagy and host innate immune responses.
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