Selective autophagy: xenophagy.

Selective autophagy: xenophagy.
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选择性自噬:异种。

DOI:
10.1016/j.ymeth.2014.12.005
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发表时间:
2015-03
期刊:
影响因子:
4.8
通讯作者:
Mysorekar, Indira U.
Mysorekar, Indira U.
中科院分区:
生物学3区
文献类型:
--
作者:
Bauckman, Kyle A.;Owusu-Boaitey, Nana;Mysorekar, Indira U.

文献摘要

参考文献

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异体吞噬是一种自噬现象,特别涉及病原体和其他非宿主实体。尽管在过去十年中,人们对自噬体和入侵生物体之间关系的了解有了显着增长,但确认异体吞噬的确切步骤尚未得到彻底定义。在这里,我们描述了一种确认自噬、其与细菌入侵的相互作用以及自噬形成的特定类型(即自噬体、自溶酶体、吞噬溶酶体)的系统方法。此外,我们认为异体吞噬不仅限于病原体与自噬体的相互作用,还包括铁等非微生物实体。
Xenophagy is an autophagic phenomenon that specifically involves pathogens and other non-host entities. Although the understanding of the relationship between autophagosomes and invading organisms has grown significantly in the past decade, the exact steps to confirm xenophagy has been not been thoroughly defined. Here we describe a methodical approach to confirming autophagy, its interaction with bacterial invasion, as well as the specific type of autophagic formation (i.e. autophagosome, autolysosome, phagolysosome). Further, we argue that xenophagy is not limited to pathogen interaction with autophagosome, but also non-microbial entities such as iron.
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