Gut Microbial Profile Is Associated With the Severity of Social Impairment and IQ Performance in Children With Autism Spectrum Disorder.
Gut Microbial Profile Is Associated With the Severity of Social Impairment and IQ Performance in Children With Autism Spectrum Disorder.
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DOI：
10.3389/fpsyt.2021.789864
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发表时间：
2021
影响因子：
4.7
通讯作者：
Li F
中科院分区：
文献类型：
--
作者：
Chen Z;Shi K;Liu X;Dai Y;Liu Y;Zhang L;Du X;Zhu T;Yu J;Fang S;Li F
背景和目的：自闭症谱系障碍（ASD）是指一组具有不同症状严重程度和合并症的异质性神经发育障碍。尽管在ASD患者中已经报道了肠道微生物群的改变，但仍不清楚某些微生物模式是否与ASD的特定症状或合并症有关。我们的目的是研究肠道微生物群与ASD儿童社会功能障碍和认知功能严重程度之间的关系。研究方法：共261名年龄匹配的儿童，包括138名诊断为ASD的儿童，63名发育迟缓或智力残疾（DD/ID）的儿童，以及60名典型发育（TD）儿童，从上海新华注册中心招募。将ASD患儿进一步分为两个亚组：76例ASD+DD患儿和62例单纯ASD患儿。通过16 S核糖体RNA测序对所有儿童的肠道微生物组进行了分析和评估。结果：肠道微生物分析表明ASD儿童的微生物群落结构发生了改变。ASD+DD和仅ASD亚组的α多样性指数显著低于DD/ID或TD组。在属的水平上，我们观察到普雷沃氏菌的相对丰度下降。同时，类杆菌和粪杆菌在ASD中显著增加，与DD/ID和TD参与者相比。所有参与者的α多样性和儿童自闭症评定量表（汽车）总分之间存在明显的相关性，这种相关性与智商表现无关。在拟杆菌属、粪杆菌属和颤螺旋菌属中观察到与汽车总分的类似相关性。然而，在所有参与者中，没有一个属与智商显著相关。结论：与DD/ID或TD组相比，在ASD或ASD亚组儿童中观察到细菌分类组成的特定变化以及与社会障碍严重程度和智商表现的相关性。这些结果表明，肠道微生物群可以作为ASD症状的有希望的生物标志物。然而，需要进一步调查。
Background and Objective: Autism spectrum disorder (ASD) refers to a heterogeneous set of neurodevelopmental disorders with diverse symptom severity and comorbidities. Although alterations in gut microbiota have been reported in individuals with ASD, it remains unclear whether certain microbial pattern is linked to specific symptom or comorbidity in ASD. We aimed to investigate the associations between gut microbiota and the severity of social impairment and cognitive functioning in children with ASD. Methods: A total of 261 age-matched children, including 138 children diagnosed with ASD, 63 with developmental delay or intellectual disability (DD/ID), and 60 typically developing (TD) children, were enrolled from the Shanghai Xinhua Registry. The children with ASD were further classified into two subgroups: 76 children diagnosed with ASD and developmental disorder (ASD+DD) and 62 with ASD only (ASD-only). The gut microbiome of all children was profiled and evaluated by 16S ribosomal RNA sequencing. Results: The gut microbial analyses demonstrated an altered microbial community structure in children with ASD. The alpha diversity indices of the ASD+DD and ASD-only subgroups were significantly lower than the DD/ID or TD groups. At the genus level, we observed a decrease in the relative abundance of Prevotella. Simultaneously, Bacteroides and Faecalibacterium were significantly increased in ASD compared with DD/ID and TD participants. There was a clear correlation between alpha diversity and the Childhood Autism Rating Scale (CARS) total score for all participants, and this correlation was independent of IQ performance. Similar correlations with the CARS total score were observed for genera Bacteroides, Faecalibacterium, and Oscillospira. However, there was no single genus significantly associated with IQ in all participants. Conclusions: Specific alterations in bacterial taxonomic composition and associations with the severity of social impairment and IQ performance were observed in children with ASD or ASD subgroups, when compared with DD/ID or TD groups. These results illustrate that gut microbiota may serve as a promising biomarker for ASD symptoms. Nevertheless, further investigations are warranted.
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影响因子：
10.6
作者：
Carlson AL;Xia K;Azcarate-Peril MA;Goldman BD;Ahn M;Styner MA;Thompson AL;Geng X;Gilmore JH;Knickmeyer RC
通讯作者：
Knickmeyer RC
微生物群转移疗法改变肠道生态系统并改善胃肠道和自闭症症状：一项开放标签研究。
影响因子：
15.5
作者：
Kang DW;Adams JB;Gregory AC;Borody T;Chittick L;Fasano A;Khoruts A;Geis E;Maldonado J;McDonough-Means S;Pollard EL;Roux S;Sadowsky MJ;Lipson KS;Sullivan MB;Caporaso JG;Krajmalnik-Brown R
通讯作者：
Krajmalnik-Brown R
结合16S rRNA基因变量区域可以实现高分辨率微生物社区分析。
影响因子：
15.5
作者：
Fuks G;Elgart M;Amir A;Zeisel A;Turnbaugh PJ;Soen Y;Shental N
通讯作者：
Shental N
DOI：
10.1097/chi.obo13e3181799f7c
发表时间：
2008-08-01
影响因子：
13.3
作者：
Goodlin-Jones, Beth L.;Tang, Karen;Anders, Thomas F.
通讯作者：
Anders, Thomas F.
自闭症谱系障碍。
DOI：
10.1038/s41572-019-0138-4
发表时间：
2020-01-16
期刊：
Nature reviews. Disease primers
影响因子：
--
作者：
Lord C;Brugha TS;Charman T;Cusack J;Dumas G;Frazier T;Jones EJH;Jones RM;Pickles A;State MW;Taylor JL;Veenstra-VanderWeele J
通讯作者：
Veenstra-VanderWeele J