Infant Gut Microbiome Associated With Cognitive Development.
Infant Gut Microbiome Associated With Cognitive Development.
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DOI：
10.1016/j.biopsych.2017.06.021
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发表时间：
2018-01-15
影响因子：
10.6
通讯作者：
Knickmeyer RC
中科院分区：
文献类型：
--
作者：
Carlson AL;Xia K;Azcarate-Peril MA;Goldman BD;Ahn M;Styner MA;Thompson AL;Geng X;Gilmore JH;Knickmeyer RC
对啮齿动物的研究提供了令人信服的证据，证明肠道中的微生物影响神经发育。特别是，改变肠道微生物区系的实验操作会影响探索和交流行为以及认知表现。在人类中，生命的头几年是肠道定居和大脑发育的动态时期，但人们对这两个过程之间的关系知之甚少。我们使用早期学习的马伦量表测试了1岁时的微生物组成是否与认知结果有关，并使用结构磁共振技术测试了1岁和2岁时的全球和区域脑容量。粪便样本采集自89名典型的发育中的一岁婴儿。16S rRNA扩增序列测定用于细菌分类群的鉴定和相对定量。聚类分析确定了3组婴儿的细菌组成。马伦在2岁时的得分在不同的组之间存在显著差异。此外，在2岁时，阿尔法多样性越高，总体综合得分、视觉接受量表和表达语言量表的得分就越低。对神经成像数据的探索性分析表明，肠道微生物群对1岁和2岁儿童的局部大脑体积影响很小。这是第一个证明肠道微生物区系与人类婴儿认知之间关系的研究。因此，这是将动物数据转化为临床的关键的第一步。
Studies in rodents provide compelling evidence that microorganisms inhabiting the gut influence neurodevelopment. In particular, experimental manipulations that alter intestinal microbiota impact exploratory and communicative behaviors and cognitive performance. In humans, the first years of life are a dynamic time in gut colonization and brain development, but little is known about the relationship between these two processes. We tested whether microbial composition at 1 year of age is associated with cognitive outcomes using the Mullen Scales of Early Learning and with global and regional brain volumes using structural MRI at 1 and 2 years of age. Fecal samples were collected from 89 typically developing one-year-old infants. 16S rRNA amplicon sequencing was used for identification and relative quantification of bacterial taxa. Cluster analysis identified 3 groups of infants defined by their bacterial composition. Mullen scores at age 2 differed significantly between clusters. In addition, higher alpha diversity was associated with lower scores on the overall composite score, visual reception scale, and expressive language scale at age 2. Exploratory analyses of neuroimaging data suggest the gut microbiome has minimal effects on regional brain volumes 1 and 2 years of age. This is the first study to demonstrate associations between the gut microbiota and cognition in human infants. As such, it represents an essential first step in translating animal data into the clinic.
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影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
DOI：
10.1073/pnas.0807920105
发表时间：
2008-11-18
影响因子：
11.1
作者：
Fierer, Noah;Hamady, Micah;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
15.1
作者：
Jiang, Haiyin;Ling, Zongxin;Ruan, Bing
通讯作者：
Ruan, Bing
影响因子：
12.2
作者：
Dogra S;Sakwinska O;Soh SE;Ngom-Bru C;Brück WM;Berger B;Brüssow H;Karnani N;Lee YS;Yap F;Chong YS;Godfrey KM;Holbrook JD
通讯作者：
Holbrook JD
影响因子：
56.9
作者：
Falony, Gwen;Joossens, Marie;Raes, Jeroen
通讯作者：
Raes, Jeroen