The structure of genetic and environmental risk factors for syndromal and subsyndromal common DSM-IV axis I and all axis II disorders.
The structure of genetic and environmental risk factors for syndromal and subsyndromal common DSM-IV axis I and all axis II disorders.
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DOI：
10.1176/appi.ajp.2010.10030340
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发表时间：
2011-01
期刊：
影响因子：
--
通讯作者：
Reichborn-Kjennerud T
中科院分区：
文献类型：
--
作者：
Kendler KS;Aggen SH;Knudsen GP;Røysamb E;Neale MC;Reichborn-Kjennerud T
作者试图阐明22种DSM-IV疾病的遗传和环境风险因素的结构：12种常见的轴I疾病和所有10种轴II疾病。作者检查了综合征和亚综合征轴I诊断和五个类别，反映了2,111名挪威公共卫生研究所双胞胎小组的年轻成年成员中认可的轴II疾病标准的数量。确定了四个相关的遗传因素：轴I内化，轴II内化，轴I外化，轴II外化。因素1和2以及因素3和4适度相关，支持内化-外化区别的重要性。五种精神障碍在两个因素上有很大的负荷：边缘型人格障碍（因素3和4），躯体形式障碍（因素1和2），偏执和依赖型人格障碍（因素2和4），饮食障碍（因素1和4）。确定了三个相关的环境因素：轴II障碍，轴I内化障碍，外化障碍与焦虑症。常见的轴I和轴II精神障碍具有一致的潜在遗传结构，反映了两个主要方面：内化与外化，轴I与轴II。环境影响的基本结构是完全不同的。将常见的精神疾病组织成连贯的群体主要是遗传因素，而不是环境因素。这些结果应解释的背景下，不可避免的局限性，目前的统计方法适用于这一数量的诊断类别。
The authors sought to clarify the structure of the genetic and environmental risk factors for 22 DSM-IV disorders: 12 common axis I disorders and all 10 axis II disorders. The authors examined syndromal and subsyndromal axis I diagnoses and five categories reflecting number of endorsed criteria for axis II disorders in 2,111 personally interviewed young adult members of the Norwegian Institute of Public Health Twin Panel. Four correlated genetic factors were identified: axis I internalizing, axis II internalizing, axis I externalizing, and axis II externalizing. Factors 1 and 2 and factors 3 and 4 were moderately correlated, supporting the importance of the internalizing-externalizing distinction. Five disorders had substantial loadings on two factors: borderline personality disorder (factors 3 and 4), somatoform disorder (factors 1 and 2), paranoid and dependent personality disorders (factors 2 and 4), and eating disorders (factors 1 and 4). Three correlated environmental factors were identified: axis II disorders, axis I internalizing disorders, and externalizing disorders versus anxiety disorders. Common axis I and II psychiatric disorders have a coherent underlying genetic structure that reflects two major dimensions: internalizing versus externalizing, and axis I versus axis II. The underlying structure of environmental influences is quite different. The organization of common psychiatric disorders into coherent groups results largely from genetic, not environmental, factors. These results should be interpreted in the context of unavoidable limitations of current statistical methods applied to this number of diagnostic categories.
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影响因子：
17.7
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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