Clinical features of behavioral symptoms in patients with semantic dementia: Does semantic dementia cause autistic traits?
Clinical features of behavioral symptoms in patients with semantic dementia: Does semantic dementia cause autistic traits?
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DOI：
10.1371/journal.pone.0247184
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Takebayashi M
中科院分区：
文献类型：
--
作者：
Sakuta S;Hashimoto M;Ikeda M;Koyama A;Takasaki A;Hotta M;Fukuhara R;Ishikawa T;Yuki S;Miyagawa Y;Hidaka Y;Kaneda K;Takebayashi M
目的：使用一种为自闭症谱系障碍患者开发的测试工具，研究语义性痴呆（SD）的行为特征。采用日本广泛性发育障碍孤独症协会评定量表（PARS）对20例SD患者和20例阿尔茨海默病（AD）患者在临床前状态和痴呆状态下的行为症状进行评价。SD组在与刻板印象和社会障碍相关的四种行为中表现出较高的患病率：吃很少的食物，自私，难以识别他人的感觉和想法，以及字面上解释语言。PARS简短版对自闭症谱系障碍的诊断敏感，在痴呆状态下的评分显著高于临床前状态下的评分，（分别为11.5 ± 6.0和1.7 ± 2.5; t（19）= 6.7，p < 0.001）和AD（分别为6.9 ± 4.6和1.7 ± 2.0; t（19）= 5.1，p < 0.001）组。在痴呆发作后，SD和AD组的PARS简短版评分均增加，尽管SD组的增加幅度显著更大（F = 5.6，p = 0.023）。此外，SD组（75%）中超过痴呆状态下自闭症诊断截止评分的患者比例显著高于AD组（40%; χ2 = 5.0，p = 0.025）。仅在SD组中，痴呆状态下的PARS评分与疾病持续时间（r = 0.46，p = 0.04）和简易精神状态检查评分（r =-0.75，p < 0.001）显著相关。虽然SD和自闭症谱系障碍是病因不同的疾病，语义性痴呆患者的行为与自闭症谱系障碍患者相似。我们的研究结果表明这两种疾病的症状相似。
To investigate the behavioral characteristics of semantic dementia (SD) using an instrument originally developed for patients with autism spectrum disorder. The behavioral symptoms of 20 patients with SD and 20 patients with Alzheimer’s disease (AD) in both the preclinical state and the dementia state were evaluated using the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS). The SD group showed high prevalence in four behaviors related to stereotypy and social impairment: eating very few food items, selfishness, difficulty in recognizing others’ feeling and thoughts, and interpreting language literally. Scores on the PARS short version, which is sensitive for diagnosis of autism spectrum disorder, were significantly higher in the dementia state than in the preclinical state in both the SD (11.5 ± 6.0 and 1.7 ± 2.5, respectively; t (19) = 6.7, p < 0.001) and AD (6.9 ± 4.6 and 1.7 ± 2.0, respectively; t (19) = 5.1, p < 0.001) groups. PARS short version scores after dementia onset increased in both the SD and AD groups, although the increase was significantly larger in the SD group (F = 5.6, p = 0.023). Additionally, a significantly higher rate of patients exceeded the cutoff score for autism diagnosis in the dementia state in the SD group (75%) than in the AD group (40%; χ2 = 5.0, p = 0.025). PARS scores in the dementia state were significantly correlated with illness duration (r = 0.46, p = 0.04) and Mini-Mental State Examination scores (r = −0.75, p < 0.001) in the SD group only. Although SD and autism spectrum disorder are etiologically distinct diseases, patients with semantic dementia behave like those with autism spectrum disorder. Our findings suggest the symptomatic similarity of the two disorders.
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影响因子：
11
作者：
Bozeat, S;Gregory, CA;Hodges, JR
通讯作者：
Hodges, JR
影响因子：
3.4
作者：
Pereira AM;Campos BM;Coan AC;Pegoraro LF;de Rezende TJR;Obeso I;Dalgalarrondo P;da Costa JC;Dreher JC;Cendes F
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Cendes F
影响因子：
5.7
作者：
Rankin, Katherine P.;Salazar, Andrea;Gorno-Tempini, Maria Luisa;Sollberger, Marc;Wilson, Stephen M.;Pavlic, Danijela;Stanley, Christine M.;Glenn, Shenly;Weiner, Michael W.;Miller, Bruce L.
通讯作者：
Miller, Bruce L.
影响因子：
14.5
作者：
Collins, Jessica A.;Montal, Victor;Dickerson, Bradford C.
通讯作者：
Dickerson, Bradford C.
影响因子：
14.5
作者：
Irish, Muireann;Hodges, John R.;Piguet, Olivier
通讯作者：
Piguet, Olivier