Differences in Cortical Structure and Functional MRI Connectivity in High Functioning Autism.
Differences in Cortical Structure and Functional MRI Connectivity in High Functioning Autism.
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DOI：
10.3389/fneur.2018.00539
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发表时间：
2018
影响因子：
3.4
通讯作者：
Cendes F
中科院分区：
文献类型：
--
作者：
Pereira AM;Campos BM;Coan AC;Pegoraro LF;de Rezende TJR;Obeso I;Dalgalarrondo P;da Costa JC;Dreher JC;Cendes F
自闭症谱系障碍(ASD)是一组复杂的神经发育疾病，以沟通和社会行为障碍为特征。我们研究了默认模式网络(DMN)的功能连接性(FC)及其与多模式形态测量的关系，以调查22名患有高功能自闭症的青少年和年轻人与年龄和智商匹配的29名健康对照组的超区域、系统水平的变化。主要结果是ASD患者的灰质(GM)减少，皮质厚度减少，几个大脑区域的皮质表面积增加，包括扣带回、颞叶和杏仁核，以及与视觉记忆编码相关的区域和DMN的感觉运动成分区域的回变增加，左半球更为明显。此外，ASD患者后扣带回皮质与DMN执行控制成分之间的连通性降低，而前额叶前内侧皮质与DMN感觉运动成分之间的FC增加。根据自闭症诊断访谈-修订版(ADI-R)的分数，右侧额叶下部皮质厚度减少与较高的社会损害相关。左侧额叶皮质厚度减少，以及右侧颞极和后扣带回皮质厚度增加，与ADI-R的沟通领域得分较差相关。我们发现ADI-R的限制性和重复行为领域的分数与结构措施或FC之间没有关联。这些结构和连接异常的结合可能有助于解释高功能ASD的一些核心行为，需要进一步研究。
Autism spectrum disorders (ASD) represent a complex group of neurodevelopmental conditions characterized by deficits in communication and social behaviors. We examined the functional connectivity (FC) of the default mode network (DMN) and its relation to multimodal morphometry to investigate superregional, system-level alterations in a group of 22 adolescents and young adults with high-functioning autism compared to age-, and intelligence quotient-matched 29 healthy controls. The main findings were that ASD patients had gray matter (GM) reduction, decreased cortical thickness and larger cortical surface areas in several brain regions, including the cingulate, temporal lobes, and amygdala, as well as increased gyrification in regions associated with encoding visual memories and areas of the sensorimotor component of the DMN, more pronounced in the left hemisphere. Moreover, patients with ASD had decreased connectivity between the posterior cingulate cortex, and areas of the executive control component of the DMN and increased FC between the anteromedial prefrontal cortex and areas of the sensorimotor component of the DMN. Reduced cortical thickness in the right inferior frontal lobe correlated with higher social impairment according to the scores of the Autism Diagnostic Interview-Revised (ADI-R). Reduced cortical thickness in left frontal regions, as well as an increased cortical thickness in the right temporal pole and posterior cingulate, were associated with worse scores on the communication domain of the ADI-R. We found no association between scores on the restrictive and repetitive behaviors domain of ADI-R with structural measures or FC. The combination of these structural and connectivity abnormalities may help to explain some of the core behaviors in high-functioning ASD and need to be investigated further.
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DOI：
10.1093/cercor/bhp289
发表时间：
2010-09
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Blaizot X;Mansilla F;Insausti AM;Constans JM;Salinas-Alamán A;Pró-Sistiaga P;Mohedano-Moriano A;Insausti R
通讯作者：
Insausti R
影响因子：
1.7
作者：
Bonilha, Leonardo;Cendes, Fernando;Steiner, Carlos E.
通讯作者：
Steiner, Carlos E.
影响因子：
9.9
作者：
Casanova, MF;Buxhoeveden, DP;Roy, E
通讯作者：
Roy, E
影响因子：
9.9
作者：
Aylward, EH;Minshew, NJ;Singh, N
通讯作者：
Singh, N
影响因子：
10.6
作者：
Carper, RA;Courchesne, E
通讯作者：
Courchesne, E