Effects of endothelin in the systemic and renal vascular beds in vivo.
Effects of endothelin in the systemic and renal vascular beds in vivo.
复制标题
内皮素对体内全身和肾血管床的影响。
DOI：
10.1016/0014-2999(88)90424-4
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发表时间：
1988
影响因子：
5
通讯作者：
Hyman,A
中科院分区：
文献类型：
--
作者：
Lippton,H;Goff,J;Hyman,A
内皮素是一种新描述的新型多肽，已从培养的猪主动脉内皮细胞中分离出来（Yanagisawa 等，1988）。内皮素在大鼠中产生全身性高血压，并且最近已被证明对离体大鼠肾动脉段具有显着的收缩活性（Tomobe 等，1988；Yanagisawa 等，1988）。由于该肽对自发性高血压大鼠 (SHR) 的肾动脉节段比 Wistar-Kyoto 大鼠 (WKY) 具有更强的收缩活性，因此表明内皮素在改变高血压肾循环中发挥作用 (Tomobe 等，1988)。在本研究中，研究了静脉内（iv）和肾内（ia）注射内皮素对全身和肾血管阻力的影响。七只猫，无论性别（1.7-2.2 kg），用氯胺酮（10 mg/kg，肌肉注射）镇静，并用戊巴比妥钠（10 mg/kg，静脉注射）麻醉。对气管插管，并对股静脉和肱动脉插管，以分别进行给药和测量全身动脉压。心输出量的测量采用热稀释技术，将1ml生理盐水（22-24℃）注入心房，通过升主动脉中的热敏电阻导管检测血液温度变化来计算心输出量。剖腹手术并静脉注射 1000 单位/千克肝素后，建立了体外回路，以便血液
Endothelin is a newly described novel polypeptide that has been isolated from cultured porcine aortic endothelial cells (Yanagisawa et al., 1988). Endothelin produces systemic hypertension in the rat and has recently been shown to possess marked contractile activity on isolated rat renal arterial segments (Tomobe et al., 1988; Yanagisawa et al., 1988). Since this peptide had greater contractile activity on renal arterial segments from spontaneously hypertensive rats (SHR) than from Wistar-Kyoto rats (WKY), a role for endothelin in altering the renal circulation in hypertension was suggested (Tomobe et al., 1988). In the present study, the effects of intravenous (iv) and intrarenal (ia) injections of endothelin on systemic and renal vascular resistances were investigated. Seven cats of either sex (1.7-2.2 kg) were sedated with ketamine, 10 mg/kg im, and anesthetized with pentobarbital sodium (10 mg/kg iv). The trachea was intubated and a femoral vein and brachial artery were cannulated to permit drug administration and measurement of systemic arterial pressure, respectively. Cardiac output was measured by thermodilution technique, injecting 1 ml of normal saline (22-24 o C) into the fight atrium and computing cardiac output by detecting blood temperature changes with a thermistor catheter in the ascending aorta. Following laparotomy and heparin administration, 1000 Units/kg iv, an extracorporeal circuit was established so that blood
影响因子：
3.5
作者：
ITOH, Y;YANAGISAWA, M;MASAKI, T
通讯作者：
MASAKI, T
内皮素对自发性高血压大鼠和 Wistar京都大鼠肾动脉的影响。
影响因子：
5
作者：
Y. Tomobe;Takashi Miyauchi;A. Saito;Masashi Yanagisawa;Sadao Kimura;K. Goto;Tomoh Masaki
通讯作者：
Tomoh Masaki
影响因子：
64.8
作者：
YANAGISAWA, M;KURIHARA, H;MASAKI, T
通讯作者：
MASAKI, T