Inflammatory events in asthma: an expanding equation.
Inflammatory events in asthma: an expanding equation.
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哮喘中的炎症事件：一个不断扩大的方程式。
DOI：
10.1067/mai.2000.106155
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
R. Lemanske
中科院分区：
文献类型：
--
作者：
R. Lemanske
哮喘是一种慢性炎症性疾病，可导致一些患者肺功能进行性、潜在不可逆的下降。当炎症细胞与常驻细胞的顺序相互作用产生一系列事件，导致慢性炎症和与疾病相关的临床表现，包括进一步的炎症、气道平滑肌痉挛（支气管痉挛）、气道粘液分泌、气道水肿和狭窄以及支气管上皮损伤时，哮喘性炎症就发生了。由于哮喘性炎症的慢性、进行性和发病年龄较早，评估儿童炎症的能力将是有用的。一些量化炎症介质（外周血、诱导痰、支气管肺泡灌洗液和支气管活检）的方法已显示出在评估和监测哮喘儿童（以及成人）疾病严重程度方面的潜在有用性。进一步的研究需要致力于阐明炎症过程何时开始以及如何随时间变化，确定炎症过程在所有喘息患者中是否相同，无论刺激如何，定义特应性和哮喘之间的关系，以及建立炎症标记物测试的有用性，以帮助识别个体哮喘表型，评估疾病严重程度。测量治疗反应，和/或预测潜在的结果。
Asthma is a chronic inflammatory disorder that can lead to progressive, potentially irreversible declines in lung function in some patients. Asthmatic inflammation develops when the sequential interaction of inflammatory cells with resident cells generates a cascade of events that contribute to the chronic inflammation and clinical manifestations associated with the disease, including further inflammation, airway smooth muscle spasm (bronchospasm), airway mucus secretion, airway edema and narrowing, and bronchial epithelial damage. Because of the chronic, progressive nature of asthmatic inflammation and the early age of onset, the ability to evaluate inflammation in children would be useful. Several procedures that quantify inflammatory mediators (in peripheral blood, induced sputum, bronchoalveolar lavage fluid, and bronchial biopsies) have shown potential usefulness in the evaluation of and the monitoring of disease severity in children (and, by extension, adults) with asthma. Further research needs to be devoted to the elucidation of when the inflammatory process starts and how it changes over time, to the determination of whether the inflammatory process is the same in all patients with wheezing, regardless of the stimulus, to the definition of the relationship between atopy and asthma, and to the establishment of the usefulness of testing for inflammatory markers to help identify individual asthmatic phenotypes, to evaluate disease severity, to measure therapeutic response, and/or to predict potential outcomes.
影响因子：
14.2
作者：
BROIDE, DH;LOTZ, M;WASSERMAN, SI
通讯作者：
WASSERMAN, SI