Acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome secondary to treatment of other malignant diseases. II. Bone marrow cytology, cytogenetics, results of HLA typing, response to antileukemic chemotherapy, and survival in a total series of 55 patients
Acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome secondary to treatment of other malignant diseases. II. Bone marrow cytology, cytogenetics, results of HLA typing, response to antileukemic chemotherapy, and survival in a total series of 55 patients
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急性非淋巴细胞白血病、白血病前期和继发于其他恶性疾病治疗的急性骨髓增生综合征。
作者：
J. Pedersen‐Bjergaard;P. Philip;N. T. Pedersen;K. Hou‐Jensen;A. Svejgaard;G. Jensen;N. Nissen
继发性急性非淋巴细胞白血病或其早期阶段，白血病前期或急性骨髓增生综合征与难治性血细胞减少症和克隆性细胞遗传学异常的骨髓，被诊断为55例患者先前治疗的其他恶性疾病。在明显的白血病患者中，细胞学和细胞化学研究显示法国-美国-英国（FAB）型M2占优势。细胞遗传学检查显示正常核型11例，而克隆异常观察44例。7号染色体缺失24例，最常见为-7号，5号染色体缺失14例，最常见为5 q-。此外，3号和17号染色体可能是非随机参与。在原发性急性非淋巴细胞白血病中常见的其他异常，如t（8;21）和t（15;17），未观察到，在继发性白血病中罕见+8。白血病并发症的生存期很短，整个组的55例患者（中位数，7个月）。然而，与其余33例多核型异常的患者相比，在11例核型正常的患者亚组中（P < 0.01），由于对抗白血病化疗的良好反应，以及在11例细胞遗传学异常为−7或−C的患者亚组中（P < 0.01），由于白血病前期延长，观察到生存期显著延长。3名-7的白血病前期患者在转化为明显白血病的过程中都出现了额外的细胞遗传学异常。根据恶性转化的两步或多步假说，在仅有-7异常的患者中，白血病前期病程延长可能代表了一个癌前阶段，在此阶段需要进一步演变才能发展为明显的白血病。患者的血型和HLA类型呈随机分布。
Secondary acute nonlymphocytic leukemia or its earlier stages, preleukemia or an acute myeloproliferative syndrome with refractory cytopenia and clonal cytogenetic abnormalities of the bone marrow, was diagnosed in 55 patients previously treated for other malignant diseases. In patients with overt leukemia, cytologic, and cytochemical studies showed predominance of the French–American–British (FAB) type M2. Cytogenetic examination demonstrated a normal karyotype in 11 cases, whereas clonal abnormalities were observed in 44 patients. Defects of chromosome 7 were observed in 24 cases, most often –7, and defects of chromosome 5 in 14 cases, most often 5q–. In addition, chromosomes 3 and 17 were possibly nonrandomly involved. Other abnormalities commonly observed in de novo acute nonlymphocytic leukemia as t(8;21) and t(15;17) were not observed and +8 rarely seen in secondary leukemia. The survival from the leukemic complication was short for the whole group of 55 patients (median, 7 months). However, a significantly longer survival was observed in a subgroup of 11 patients with a normal karyotype (P < 0.01), due to a favorable response to antileukemic chemotherapy, and in a subgroup of 11 patients with −7 or −C as the only cytogenetic abnormality (P < 0.01), due to a prolonged preleukemic phase, compared with the remaining 33 cases with mostly multiple karyotypic abnormalities. Three preleukemic patients with −7 who were studied during transformation to overt leukemia all developed additional cytogenetic abnormalities. According to the two‐step or multistep hypothesis for malignant transformation, the prolonged preleukemic course in patients with −7 as the only abnormality could represent a premalignant stage, in which further evolution is required for development of overt leukemia. The patients showed a random distribution of blood groups and HLA types.
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影响因子：
3.1
作者：
J. Rowley;H. Golomb;J. Vardiman
通讯作者：
J. Rowley;H. Golomb;J. Vardiman
影响因子：
20.3
作者：
J. Rowley;H. Golomb;J. Vardiman
通讯作者：
J. Rowley;H. Golomb;J. Vardiman
急性非淋巴细胞白血病形态类型与患者年龄和核型关系的合作研究。
影响因子：
20.3
作者：
Rowley,JD;Alimena,G;Garson,OM;Hagemeijer,A;Mitelman,F;Prigogina,EL
通讯作者：
Prigogina,EL
霍奇金病并发的第二种恶性肿瘤：西南肿瘤学组 10 年随访。
DOI：
--
发表时间：
1982
期刊：
Cancer treatment reports
影响因子：
--
作者：
ColtmanJr,CA;Dixon,DO
通讯作者：
Dixon,DO
染色体与人类癌症和白血病的病因。
影响因子：
--
作者：
Sandberg,AA;Abe,S;Kowalczyk,JR;Zedgenidze,A;Takeuchi,J;Kakati,S
通讯作者：
Kakati,S