Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality.
Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality.
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DOI：
10.1007/s00134-009-1560-y
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发表时间：
2009-09
影响因子：
38.9
通讯作者：
Groeneveld, A. B. Johan
中科院分区：
文献类型：
--
作者：
van der Heijden, Melanie;Pickkers, Peter;Amerongen, Geerten P. van Nieuw;van Hinsbergh, Victor W. M.;Bouw, Martijn P. W. J. M.;van der Hoeven, Johannes G.;Groeneveld, A. B. Johan
探讨血管生成素-2、血管性血友病因子（VWF）和血管生成素-1是否与感染性休克过程中血管通透性、肺功能障碍和重症监护室（ICU）死亡率的替代指标相关。在50例连续机械通气脓毒性休克患者中，分别测量血浆血管生成素-2，VWF和血管生成素-1水平和液体平衡，氧分压/吸入氧分数和氧合指数作为血管通透性和肺功能障碍的指标，直至第28天。Angiopoietin-2与液体平衡和肺功能障碍呈正相关，在死亡者中高于存活者，并独立预测整个感染性休克过程中的死亡率。VWF与脓毒性休克过程中的液体平衡和肺功能障碍呈负相关，在存活者和非存活者之间具有可比性，仅在第0天预测非存活。血管生成素-1在整个过程中与肺功能障碍呈正相关，但在幸存者和非幸存者之间没有差异。与VWF相反，血浆血管生成素-2与脓毒性休克过程中的液体平衡、肺功能障碍和死亡率呈正相关，这与该蛋白的介导作用一致。本文的在线版本（doi：10.1007/s 00134 -009-1560-y）包含补充材料，可供授权用户使用。
To investigate whether angiopoietin-2, von Willebrand factor (VWF) and angiopoietin-1 relate to surrogate indicators of vascular permeability, pulmonary dysfunction and intensive care unit (ICU) mortality throughout the course of septic shock. In 50 consecutive mechanically ventilated septic shock patients, plasma angiopoietin-2, VWF and angiopoietin-1 levels and fluid balance, partial pressure of oxygen/inspiratory oxygen fraction and the oxygenation index as indicators of vascular permeability and pulmonary dysfunction, respectively, were measured until day 28. Angiopoietin-2 positively related to the fluid balance and pulmonary dysfunction, was higher in non-survivors than in survivors and independently predicted non-survival throughout the course of septic shock. VWF inversely related to the fluid balance and pulmonary dysfunction throughout the course of septic shock, was comparable between survivors and non-survivors and predicted non-survival on day 0 only. Angiopoietin-1 positively related to pulmonary dysfunction throughout the course, but did not differ between survivors and non-survivors. In contrast to VWF, plasma angiopoietin-2 positively relates to fluid balance, pulmonary dysfunction and mortality throughout the course of septic shock, in line with a suggested mediator role of the protein. The online version of this article (doi:10.1007/s00134-009-1560-y) contains supplementary material, which is available to authorized users.
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