Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan.
Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan.
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二氢叶酸还原酶是三氯生的抗疟疾作用的第二个酶靶标。
DOI：
10.1038/s41598-018-19549-x
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发表时间：
2018-01-18
影响因子：
4.6
通讯作者：
Oliver SG
中科院分区：
文献类型：
--
作者：
Bilsland E;van Vliet L;Williams K;Feltham J;Carrasco MP;Fotoran WL;Cubillos EFG;Wunderlich G;Grøtli M;Hollfelder F;Jackson V;King RD;Oliver SG
Malaria, caused by parasites of the genus Plasmodium, leads to over half a million deaths per year, 90% of which are caused by Plasmodium falciparum. P. vivax usually causes milder forms of malaria; however, P. vivax can remain dormant in the livers of infected patients for weeks or years before re-emerging in a new bout of the disease. The only drugs available that target all stages of the parasite can lead to severe side effects in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency; hence, there is an urgent need to develop new drugs active against blood and liver stages of the parasite. Different groups have demonstrated that triclosan, a common antibacterial agent, targets the Plasmodium liver enzyme enoyl reductase. Here, we provide 4 independent lines of evidence demonstrating that triclosan specifically targets both wild-type and pyrimethamine-resistant P. falciparum and P. vivax dihydrofolate reductases, classic targets for the blood stage of the parasite. This makes triclosan an exciting candidate for further development as a dual specificity antimalarial, which could target both liver and blood stages of the parasite.
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影响因子：
3.8
作者：
Bilsland E;Pir P;Gutteridge A;Johns A;King RD;Oliver SG
通讯作者：
Oliver SG
影响因子：
5.8
作者：
Bilsland E;Sparkes A;Williams K;Moss HJ;de Clare M;Pir P;Rowland J;Aubrey W;Pateman R;Young M;Carrington M;King RD;Oliver SG
通讯作者：
Oliver SG
影响因子：
11.4
作者：
Han, Jie;Qiu, Wei;Xing, Baoshan
通讯作者：
Xing, Baoshan
影响因子：
4.8
作者：
Perozzo, R;Kuo, M;Sacchettini, JC
通讯作者：
Sacchettini, JC
影响因子：
4.9
作者：
Chugh, Monika;Scheurer, Christian;Ding, Xavier C.
通讯作者：
Ding, Xavier C.