Gene-environment interactions and their impact on human health.
Gene-environment interactions and their impact on human health.
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基因-环境相互作用及其对人类健康的影响。
DOI：
10.1038/s41435-022-00192-6
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发表时间：
2023-02
影响因子：
5
通讯作者：
中科院分区：
文献类型：
--
作者：
The molecular processes underlying human health and disease are highly complex. Often, genetic and environmental factors contribute to a given disease or phenotype in a non-additive manner, yielding a gene–environment (G × E) interaction. In this work, we broadly review current knowledge on the impact of gene–environment interactions on human health. We first explain the independent impact of genetic variation and the environment. We next detail well-established G × E interactions that impact human health involving environmental toxicants, pollution, viruses, and sex chromosome composition. We conclude with possibilities and challenges for studying G × E interactions.
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DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Casanova JL
影响因子：
14.9
作者：
Buniello, Annalisa;MacArthur, Jacqueline A. L.;Parkinson, Helen
通讯作者：
Parkinson, Helen
DOI：
10.1084/jem.20220202
发表时间：
2022-07-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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通讯作者：
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