14-3-3ζ as a prognostic marker and therapeutic target for cancer.
14-3-3ζ as a prognostic marker and therapeutic target for cancer.
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DOI：
10.1517/14728222.2010.531011
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发表时间：
2010-12
影响因子：
5.8
通讯作者：
Yu D
中科院分区：
文献类型：
--
作者：
Neal CL;Yu D
广泛表达的14-3-3 β蛋白参与许多与癌症有关的重要细胞通路。最近的研究表明，14-3-3 β可能在调节癌症发生和发展的多个途径中发挥核心作用。本文将对14-3-3蛋白进行综述，并探讨14-3-3蛋白过度表达在癌症中的作用。该综述涵盖了14-3-3在调节多种途径中的基本作用，重点是14-3-3作为癌症复发的临床相关生物标志物。14-3-3 β过表达已在多种癌症中发现;然而，临床意义尚不清楚。近年来，14-3-3 β 1已被鉴定为多种肿瘤类型中预后不良和化疗耐药性的生物标志物，表明使用14-3-3 β 1在选择治疗方案和预测癌症患者的结果方面具有潜在的临床应用。14-3-3 β是癌症复发的潜在预后标志物和治疗抗性的预测标志物。14-3-3抑制剂在多种癌症中的过表达表明，它可能是干预肿瘤进展的共同靶点;因此，需要更多的努力来开发14-3-3抑制剂。
The ubiquitously expressed 14-3-3ζ protein is involved in numerous important cellular pathways involved in cancer. Recent research suggests 14-3-3ζ may play a central role regulating multiple pathways responsible for cancer initiation and progression. This review will provide an overview of 14-3-3 proteins and address the role of 14-3-3ζ overexpression in cancer. The review covers the basic role of 14-3-3 in regulation of multiple pathways with a focus on 14-3-3ζ as a clinically relevant biomarker for cancer recurrence. 14-3-3ζ overexpression has been found in multiple cancers; however, the clinical implications were unclear. Recently, 14-3-3ζ has been identified as a biomarker for poor prognosis and chemoresistance in multiple tumor types, indicating a potential clinical application for using 14-3-3ζ in selecting treatment options and predicting cancer patients’ outcome. 14-3-3ζ is a potential prognostic marker of cancer recurrence and predictive marker for therapeutic resistance. The overexpression of 14-3-3ζ in multiple cancers suggests that it may be a common target to intervene tumor progression; therefore, more efforts are needed for the development of 14-3-3 inhibitors.
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影响因子：
64.5
作者：
Brunet, A;Bonni, A;Greenberg, ME
通讯作者：
Greenberg, ME
DOI：
10.1038/npp.2008.172
发表时间：
2009-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
--
作者：
Du, YH;Masters, SC;Fu, H
通讯作者：
Fu, H
DOI：
10.1101/sqb.1994.059.01.023
发表时间：
1994-01-01
期刊：
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
影响因子：
--
作者：
FREED, E;MCCORMICK, F;RUGGIERI, R
通讯作者：
RUGGIERI, R
影响因子：
3.7
作者：
Garnis, C;Coe, BP;Lam, WL
通讯作者：
Lam, WL