New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions.

New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions.
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CTRP3 对肥胖、代谢功能障碍和心血管疾病影响的新见解:治疗干预的潜力。

DOI:
10.3389/fphys.2020.570270
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发表时间:
2020
影响因子:
4
通讯作者:
Yuan LQ
Yuan LQ
中科院分区:
医学2区
文献类型:
--
作者:
Guo B;Zhuang T;Xu F;Lin X;Li F;Shan SK;Wu F;Zhong JY;Wang Y;Zheng MH;Xu QS;Ehsan UMH;Yuan LQ

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脂肪组织作为人体最大的内分泌器官,分泌许多具有生物活性的分子,在血液中循环,统称为脂肪细胞因子,它们不仅调节代谢,而且在病理生理过程中发挥作用。C1 q肿瘤坏死因子相关蛋白3(C1 q tumor necrosis factor-related protein 3,CTRP 3)是C1 q肿瘤坏死因子相关蛋白(C1 q tumor necrosis factor-related proteins,CTRPs)的一个成员,是脂联素的一个副产物。CTRP 3对葡萄糖/脂质代谢、炎症具有广泛的影响,并有助于心血管保护。本文就CTRP 3在肥胖、糖尿病、代谢综合征及心血管疾病中的最新研究进展作一综述。
Adipose tissue, as the largest endocrine organ, secretes many biologically active molecules circulating in the bloodstream, collectively termed adipocytokines, which not only regulate the metabolism but also play a role in pathophysiological processes. C1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a member of C1q tumor necrosis factor-related proteins (CTRPs), which is a paralog of adiponectin. CTRP3 has a wide range of effects on glucose/lipid metabolism, inflammation, and contributes to cardiovascular protection. In this review, we comprehensively discussed the latest research on CTRP3 in obesity, diabetes, metabolic syndrome, and cardiovascular diseases.
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