Reversal of impaired myocardial beta-adrenergic receptor signaling by continuous-flow left ventricular assist device support.
Reversal of impaired myocardial beta-adrenergic receptor signaling by continuous-flow left ventricular assist device support.
复制标题
连续流左室辅助装置支撑的心肌β-肾上腺素能受体信号传导的逆转。
DOI：
10.1016/j.healun.2010.01.010
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发表时间：
2010-06
影响因子：
8.9
通讯作者：
Jeevanandam, Valluvan
中科院分区：
文献类型：
--
作者：
Akhter, Shahab A.;D'Souza, Karen M.;Malhotra, Ricky;Staron, Michelle L.;Valeroso, Tracy B.;Fedson, Savitri E.;Anderson, Allen S.;Raman, Jai;Jeevanandam, Valluvan
关键词：
Myocardial β-adrenergic receptor (β-AR) signaling is severely impaired in chronic heart failure (HF). The objective of this study is to determine if LV β-AR signaling can be restored following continuous-flow LVAD support. Paired LV biopsies were obtained at the time of HeartMate II LVAD implant (HF group) and transplant (LVAD group). The mean duration of LVAD support was 152 ± 34 days. Myocardial β-AR signaling was assessed by measuring adenylyl cyclase (AC) activity, total β-AR density (Bmax), and GRK2 expression and activity. All patients underwent LVAD implant as a bridge to transplant (n=12). LV specimens from non-failing hearts (NF) were used as controls (n=8). Basal and isoproterenol (ISO)-stimulated AC activity was significantly lower in HF vs. NF indicative of β-AR uncoupling. Continuous-flow LVAD support restored basal and ISO-stimulated cyclase activity to levels similar to NF. Bmax was decreased in HF versus NF and increased to near normal in the LVAD group. GRK2 expression was increased 2.6-fold in HF versus NF and was similar to NF following LVAD support. Similarly, GRK2 activity was 3.2-fold greater in HF versus NF and decreased to NF levels in the LVAD group. Myocardial β-AR signaling can be restored to near normal following continuous-flow LVAD support. This is similar to previous data for volume displacement, pulsatile LVADs. Decreased GRK2 activity appears to be an important mechanism and indicates that normalization of the neurohormonal milieu associated with HF is similar between continuous-flow and pulsatile LVADs. This may have important implications for myocardial recovery.
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影响因子：
37.8
作者：
UNGERER, M;BOHM, M;LOHSE, MJ
通讯作者：
LOHSE, MJ
DOI：
10.1152/ajpheart.00908.2005
发表时间：
2006-04-01
影响因子：
4.8
作者：
Akhter, SA;D'Souza, KM;Liggett, SB
通讯作者：
Liggett, SB
影响因子：
37.8
作者：
Akhter, SA;Eckhart, AD;Koch, WJ
通讯作者：
Koch, WJ
影响因子：
37.8
作者：
JAMES, KB;MCCARTHY, PM;BRAVO, E
通讯作者：
BRAVO, E
DOI：
10.1016/s0022-5223(98)70327-7
发表时间：
1998-03-01
影响因子：
6
作者：
Kypson, AP;Peppel, K;Koch, WJ
通讯作者：
Koch, WJ