Contrast-enhanced MRI of carotid atherosclerosis: dependence on contrast agent.
Contrast-enhanced MRI of carotid atherosclerosis: dependence on contrast agent.
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DOI：
10.1002/jmri.21826
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发表时间：
2009-07
影响因子：
4.4
通讯作者：
Zhao, Xueqiao
中科院分区：
文献类型：
--
作者：
Kerwin, William S.;Zhao, Xihai;Yuan, Chun;Hatsukami, Thomas S.;Maravilla, Kenneth R.;Underhill, Hunter R.;Zhao, Xueqiao
目的：探讨颈动脉粥样硬化斑块MRI造影增强对加多苯二胺与加多二胺使用的依赖性。15例有颈动脉粥样硬化斑块的受试者分别以0.1 mmol/kg剂量成像。对于具有可解释图像的动脉，测量管腔、管壁、坏死核心和上覆纤维帽（如果存在）的面积，以及增强百分比和噪声对比比（CNR）。动力学模型应用于动态成像结果，以确定分数血浆体积vp和造影剂传递常数Ktrans。对于12名具有可解释图像的受试者，使用的药物对任何面积测量或坏死核心的存在与否没有显著影响（所有受试者的p < 0.01）。然而，当使用gadobenate二聚胺时，纤维帽（72%对54%，p<0.05）坏死核心（51%对42%，p=0.12）和管腔（42%对63%，p<0.05）的百分比增强更大，尽管CNR没有明显差异。此外，使用gadobenate二聚胺时Ktrans较低（0.0846 min - 1 vs. 0.101 min - 1, p<0.01），尽管vp无差异（9.5% vs. 10.1%, p=0.39）。斑块形态测量与两种造影剂相似，但定量增强特征，如增强百分比和Ktrans不同。
To investigate the dependence of contrast-enhanced MRI of carotid artery atherosclerotic plaque on use of gadobenate dimeglumine versus gadodiamide. 15 subjects with carotid atherosclerotic plaque were imaged with 0.1 mmol/kg of each agent. For arteries with interpretable images, the areas of the lumen, wall, and necrotic core and overlying fibrous cap (when present) were measured, as were the percent enhancement and contrast-to-noise ratio (CNR). A kinetic model was applied to dynamic imaging results to determine the fractional plasma volume vp and contrast agent transfer constant Ktrans. For 12 subjects with interpretable images, the agent used did not significantly impact any area measurements or the presence or absence of necrotic core (p>0.1 for all). However, the percent enhancement was greater for the fibrous cap (72% vs. 54%; p<0.05) necrotic core (51% vs. 42%; p=0.12), and lumen (42% vs. 63%; p<0.05) when using gadobenate dimeglumine, although no apparent difference in CNR was found. Additionally, Ktrans was lower when using gadobenate dimeglumine (0.0846 min−1 vs. 0.101 min−1; p<0.01), although vp showed no difference (9.5% vs. 10.1%; p=0.39). Plaque morphology measurements are similar with either contrast agent, but quantitative enhancement characteristics, such as percent enhancement and Ktrans, differ.
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影响因子：
8.3
作者：
Takaya, N;Yuan, C;Hatsukami, TS
通讯作者：
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