Mosaic evolution of neural development in anurans: acceleration of spinal cord development in the direct developing frog Eleutherodactylus coqui
Mosaic evolution of neural development in anurans: acceleration of spinal cord development in the direct developing frog Eleutherodactylus coqui
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无尾目动物神经发育的马赛克进化：直接发育的青蛙脊髓发育加速
DOI：
--
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
G. Schlosser
中科院分区：
文献类型：
--
作者：
G. Schlosser
先前的研究已经表明，直接发育的Eleutherodactylus属青蛙的脊髓发育与双相发育的无尾类（幼虫和成虫阶段通过变态分开）不同，它们在进化上已经失去了蝌蚪阶段。本研究的脊髓发育Eleutherodactylus coqui提供了额外的信息，神经发生，神经元的分化和增殖细胞核抗原（PCNA），原位杂交NeuroD的免疫染色分析的生长，并在不同的发展阶段的形态测量。此外，对属于不同无尾目科但均表现出双相发育的Discoglossus pictus、Xenopus laevis和Physalaemus pustulosus的脊髓发育进行了类似的分析。这种比较分析可以推断的祖先无尾类模式的脊髓发育，以及它是如何在Eleutherodactylus的进化过程中被修改。所有双相发育的青蛙分析共享一个类似的模式的脊髓发育，这表明这是祖先的无尾两栖类：神经管关闭后，在脊髓中的增殖和神经发生的水平在整个胚胎发育低，直到他们被大幅上调，在早期幼虫阶段，其次是发展的横向电机列。而E. coqui，在神经管关闭后不久，快速生长，高水平的增殖和神经发生，以及外侧运动柱的早期形成，而中枢神经系统的其他部分发育较慢。因此，脊髓的发育在Eleutherodactylus的进化过程中相对于中枢神经系统的其他部分的发育有所加速，这可能与该谱系中肢体的早熟发育有关。
Previous studies have shown that spinal cord development in direct developing frogs of the genus Eleutherodactylus, which have evolutionarily lost the tadpole stage, differs from that in biphasically developing anurans (with the larval and the adult stage separated by metamorphosis). The present study of spinal cord development in Eleutherodactylus coqui provides additional information about neurogenesis, neuronal differentiation and growth analyzed by immunostaining for proliferating cell nuclear antigen (PCNA), in situ hybridization for NeuroD, and morphometric measurements in various developmental stages. Furthermore, spinal cord development in the frogs Discoglossus pictus, Xenopus laevis, and Physalaemus pustulosus, which belong to different anuran families but all exhibit biphasic development, was similarly analyzed. This comparative analysis allows inference of the ancestral anuran pattern of spinal cord development and how it has been modified during the evolution of Eleutherodactylus. All biphasically developing frogs analyzed share a similar pattern of spinal cord development, suggesting that this is ancestral for anurans: after neural tube closure, levels of proliferation and neurogenesis in the spinal cord were low throughout embryogenesis until they were upregulated drastically at early larval stages followed by development of the lateral motor columns. In contrast, no such quiescent embryonic period exists in E. coqui, where rapid growth, high levels of proliferation and neurogenesis, and early formation of lateral motor columns occur shortly after neural tube closure, while other parts of the central nervous system develop more slowly. Thus, spinal cord development has been accelerated during the evolution of Eleutherodactylus relative to the development of other parts of the central nervous system, probably related to the precocious development of limbs in this lineage.
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DOI：
10.1159/000113325
发表时间：
1997
期刊：
Brain, behavior and evolution
影响因子：
--
作者：
Schlosser,G;Roth,G
通讯作者：
Roth,G
发育中的脊髓中头尾模式的控制：运动神经元亚型身份的规范是由来自轴旁中胚层的信号启动的。
DOI：
10.1242/dev.125.6.969
发表时间：
1998
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Ensini,M;Tsuchida,TN;Belting,HG;Jessell,TM
通讯作者：
Jessell,TM
DOI：
10.1159/000113323
发表时间：
1997
期刊：
Brain, behavior and evolution
影响因子：
--
作者：
Schlosser,G;Roth,G
通讯作者：
Roth,G
直接发育的青蛙 Eleutherodactylus coqui 失去形成侧线基板的外胚层能力。
影响因子：
2.7
作者：
Schlosser,G;Kintner,C;Northcutt,RG
通讯作者：
Northcutt,RG