Alcohol use disorder: A pre-existing condition for COVID-19?
Alcohol use disorder: A pre-existing condition for COVID-19?
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DOI：
10.1016/j.alcohol.2020.10.003
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Wyatt TA
中科院分区：
文献类型：
--
作者：
Bailey KL;Samuelson DR;Wyatt TA
长期以来，酒精滥用被认为是肺部病理生理学的一个贡献者。多器官对酒精介导的组织损伤的反应的交叉可能有助于肺对损伤的反应的调节。事实上，酒精对感染易感性和肺屏障功能的负面影响现已得到充分证明。因此，酒精肺很可能是COVID-19易感性和严重程度的负面后果的合并症。在这篇综述中，我们介绍了在当前冠状病毒大流行的背景下已知的酒精滥用对肺部的影响。COVID-19大流行导致严重肺部疾病。慢性酒精滥用可归因于肺功能障碍。酒精诱导的先天肺防御功能受损可能会加重COVID 19感染和严重程度。
Alcohol misuse is long established as a contributor to the pathophysiology of the lung. The intersection of multi-organ responses to alcohol-mediated tissue injury likely contributes to the modulation of lung in response to injury. Indeed, the negative impact of alcohol on susceptibility to infection and on lung barrier function is now well documented. Thus, the alcohol lung represents a very likely comorbidity for the negative consequences of both COVID-19 susceptibility and severity. In this review, we present the known alcohol misuse ramifications on the lung in the context of the current coronavirus pandemic. The COVID-19 pandemic contributes to severe lung disease. Chronic alcohol misuse is attributed to lung dysfunction. Alcohol-induced impairment of innate lung defense could worsen COVID 19 infection and severity.
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影响因子：
158.5
作者：
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影响因子：
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DOI：
10.1001/jama.1923.02640380014005
发表时间：
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影响因子：
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作者：
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通讯作者：
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