Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue.
Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue.
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DOI：
10.1001/jamaoncol.2016.6374
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发表时间：
2017-07-01
期刊：
影响因子：
28.4
通讯作者：
Ogino S
中科院分区：
文献类型：
--
作者：
Mehta RS;Nishihara R;Cao Y;Song M;Mima K;Qian ZR;Nowak JA;Kosumi K;Hamada T;Masugi Y;Bullman S;Drew DA;Kostic AD;Fung TT;Garrett WS;Huttenhower C;Wu K;Meyerhardt JA;Zhang X;Willett WC;Giovannucci EL;Fuchs CS;Chan AT;Ogino S
具核梭杆菌似乎通过抑制宿主对肿瘤的免疫反应在结直肠癌发生中发挥作用。有证据表明，饮食影响肠道F。核质然而，F.核质在调节饮食和结直肠癌风险之间的关系中的作用尚不清楚。为了验证谨慎饮食（富含全谷物和膳食纤维）和西方饮食（富含红肉和加工肉类，精制谷物和甜点）与结直肠癌风险的关系可能因F的存在而不同的假设。肿瘤组织中的核质。前瞻性队列研究。护士健康研究（1980 - 2012）和卫生专业人员随访研究（1986 - 2012）。121，700名美国女性护士和51，529名美国男性卫生专业人员，年龄分别为30至55岁和40至75岁。谨慎的西方饮食模式。大肠癌的发病率按F.通过定量聚合酶链反应测定肿瘤组织中的核仁状态。我们记录了1，019例结肠癌和直肠癌病例，可获得F。主要为白色的137，217名受试者的核仁数据，随访时间为26 - 32年，涵盖3，643，562人-年。谨慎饮食与结直肠癌的关系在组织F.具核状态（P异质性=.01）。谨慎饮食评分与F.核素阳性癌症[Ptrend = 0.003;最高与最低谨慎评分四分位数的多变量风险比为0.43（95%置信区间0.25 - 0.72）]，但F.核阴性癌（Ptrend =.47）。膳食成分分析表明，根据膳食纤维的摄入量，癌症亚组可能存在差异性关联（P异质性= 0.02）。根据西方饮食模式评分，亚组之间无显著异质性（P异质性=.23）。谨慎的饮食富含全谷物和膳食纤维与较低的患F。nucleatum阳性的结直肠癌，而不是F.核阴性癌症，支持肠道微生物群在介导饮食与结直肠肿瘤之间的联系方面发挥潜在作用。
Fusobacterium nucleatum appears to play a role in colorectal carcinogenesis through suppression of host immune response to tumor. Evidence also suggests that diet influences intestinal F. nucleatum. However, the role of F. nucleatum in mediating the relationship between diet and the risk of colorectal cancer is unknown. To test the hypothesis that the associations of prudent diets (rich in whole grains and dietary fiber) and Western diets (rich in red and processed meat, refined grains, and desserts) with colorectal cancer risk may differ according to the presence of F. nucleatum in tumor tissue. Prospective cohort study. The Nurses’ Health Study (1980–2012) and the Health Professionals Follow-up Study (1986–2012). 121,700 US female nurses and 51,529 US male health professionals aged 30 to 55 years and 40 to 75 years, respectively, at enrollment. Prudent and Western dietary patterns. Incidence of colorectal carcinoma subclassified by F. nucleatum status in tumor tissue, determined by quantitative polymerase chain reaction. We documented 1,019 incident colon and rectal cancer cases with available F. nucleatum data among predominantly white 137,217 individuals over 26–32 years of follow-up encompassing 3,643,562 person-years. The association of prudent diet with colorectal cancer significantly differed by tissue F. nucleatum status (Pheterogeneity = .01). Prudent diet score was associated with a lower risk of F. nucleatum-positive cancers [Ptrend = .003; multivariable hazard ratio of 0.43 (95% confidence interval 0.25–0.72) for the highest vs. the lowest prudent score quartile], but not with F. nucleatum-negative cancers (Ptrend = .47). Dietary component analyses suggested possible differential associations for the cancer subgroups according to intakes of dietary fiber (Pheterogeneity = .02). There was no significant heterogeneity between the subgroups according to Western dietary pattern scores (Pheterogeneity = .23). Prudent diets rich in whole grains and dietary fiber are associated with a lower risk for F. nucleatum-positive colorectal cancer but not F. nucleatum-negative cancer, supporting a potential role for intestinal microbiota in mediating the association between diet and colorectal neoplasms.
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影响因子：
24.5
作者：
Mima K;Nishihara R;Qian ZR;Cao Y;Sukawa Y;Nowak JA;Yang J;Dou R;Masugi Y;Song M;Kostic AD;Giannakis M;Bullman S;Milner DA;Baba H;Giovannucci EL;Garraway LA;Freeman GJ;Dranoff G;Garrett WS;Huttenhower C;Meyerson M;Meyerhardt JA;Chan AT;Fuchs CS;Ogino S
通讯作者：
Ogino S
影响因子：
5.6
作者：
Fu BC;Randolph TW;Lim U;Monroe KR;Cheng I;Wilkens LR;Le Marchand L;Hullar MA;Lampe JW
通讯作者：
Lampe JW
影响因子：
24.5
作者：
Flemer B;Lynch DB;Brown JM;Jeffery IB;Ryan FJ;Claesson MJ;O'Riordain M;Shanahan F;O'Toole PW
通讯作者：
O'Toole PW
DOI：
10.1136/bmj.d6617
发表时间：
2011-11-10
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Aune D;Chan DS;Lau R;Vieira R;Greenwood DC;Kampman E;Norat T
通讯作者：
Norat T
影响因子：
7
作者：
Castellarin, Mauro;Warren, Rene L.;Holt, Robert A.
通讯作者：
Holt, Robert A.