Advances in the treatment of inflammatory arthritis.

Advances in the treatment of inflammatory arthritis.
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DOI:
10.1016/j.berh.2012.03.001
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发表时间:
2012-04
影响因子:
5.2
通讯作者:
Ward, Michael M.
Ward, Michael M.
中科院分区:
医学2区
文献类型:
--
作者:
Pisetsky, David S.;Ward, Michael M.

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炎症性关节炎是一组不同的疾病,以关节炎症为特征,可导致疼痛、畸形和残疾。在这些疾病中,类风湿性关节炎(RA)和脊柱关节炎是最常见的两种。虽然这些疾病的临床和人口学特征不同,但炎症在其发病机制中的核心作用使人们能够开发出具有广泛适用性的高效治疗策略。这些策略包括使用针对细胞因子肿瘤坏死因子(肿瘤坏死因子)的生物制剂,肿瘤坏死因子是炎症的关键介质。随着有效药物的出现,治疗变得更加积极,减少了疾病的活动性,并至少在RA患者中允许缓解。虽然现有的有效治疗方法种类繁多,但使用疾病活动的客观衡量标准可以指导治疗决定(针对目标进行治疗),并导致改善结果。
The inflammatory arthritides are a diverse group of conditions characterised by joint inflammation which can lead to pain, deformity and disability. Of these diseases, rheumatoid arthritis (RA) and spondyloarthritis are two of the most common. While the clinical and demographic features of these diseases differ, the central role of inflammation in their pathogenesis has allowed the development of highly effective treatment strategies with wide applicability. These strategies include the use of biological agents which target the cytokine tumour necrosis factor (TNF), a key mediator of inflammation. With the advent of effective agents, therapy has become more aggressive, reducing disease activity and allowing, at least in RA, remission in many patients. While the array of available effective treatments is extensive, the use of objective measures of disease activity can guide treatment decisions (treat to target) and lead to improved outcomes.
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