Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism.
Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism.
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DOI：
10.1136/ard.2008.098764
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发表时间：
2008-12
影响因子：
27.4
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Goldring MB;Otero M;Tsuchimochi K;Ijiri K;Li Y
在骨关节炎（OA）中，由于机械损伤和炎症，成人关节软骨细胞会对环境的改变做出反应，从而进行表型调节。这些过程不仅刺激降解软骨基质的酶的产生，而且抑制修复。随着体外和体内模型的使用，新的基因，以前不知道在软骨中发挥作用，已被确定和它们的作用，在软骨细胞分化过程中的发展和失调的软骨细胞功能在OA已被检查。这些新基因包括分别由骨形态发生蛋白（BMP）-2和炎性细胞因子诱导的生长停滞和DNA损伤（GADD）45β和上皮特异性ETS（ESE）-1转录因子。这两个基因均受NF-κB诱导，抑制COL 2A 1并上调基质金属蛋白酶-13（MMP-13）表达。这些基因也已经在OA的小鼠模型中进行了研究，其中盘状结构域受体2与MMP-13介导的重塑相关，以了解它们在生理软骨稳态和关节疾病中的作用。
In osteoarthritis (OA), adult articular chondrocytes undergo phenotypic modulation in response to alterations in the environment owing to mechanical injury and inflammation. These processes not only stimulate the production of enzymes that degrade the cartilage matrix but also inhibit repair. With the use of in vitro and in vivo models, new genes, not known previously to act in cartilage, have been identified and their roles in chondrocyte differentiation during development and in dysregulated chondrocyte function in OA have been examined. These new genes include growth arrest and DNA damage (GADD)45β and the epithelial-specific ETS (ESE)-1 transcription factor, induced by bone morpho-genetic protein (BMP)-2 and inflammatory cytokines, respectively. Both genes are induced by NF-κB, suppress COL2A1 and upregulate matrix meatalloproteinase-13 (MMP-13) expression. These genes have also been examined in mouse models of OA, in which discoidin domain receptor 2 is associated with MMP-13-mediated remodelling, in order to understand their roles in physiological cartilage homoeostasis and joint disease.
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滑膜巨噬细胞和巨噬细胞产生的细胞因子在驱动聚集蛋白聚糖酶、基质金属蛋白酶和骨关节炎中其他破坏性和炎症反应中的作用。
影响因子：
4.9
作者：
Bondeson J;Wainwright SD;Lauder S;Amos N;Hughes CE
通讯作者：
Hughes CE
DOI：
10.1097/01.mco.0000068964.34812.2b
发表时间：
2003-05-01
影响因子：
3.1
作者：
Deschner, J;Hofman, CR;Agarwal, S
通讯作者：
Agarwal, S
影响因子：
--
作者：
Dossumbekova, Anar;Anghelina, Mirela;Agarwal, Sudha
通讯作者：
Agarwal, Sudha
影响因子：
--
作者：
Bobacz, K.;Sunk, I. G.;Smolen, J. S.
通讯作者：
Smolen, J. S.
影响因子：
2.4
作者：
Alexopoulos, LG;Williams, GM;Guilak, F
通讯作者：
Guilak, F