Relapsing fever borreliosis in interleukin-10-deficient mice.
Relapsing fever borreliosis in interleukin-10-deficient mice.
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白细胞介素 10 缺陷小鼠的回归热疏螺旋体病。
DOI：
10.1128/iai.00587-08
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发表时间：
2008
影响因子：
3.1
通讯作者：
Cadavid,Diego
中科院分区：
文献类型：
--
作者：
Londoño,Diana;Marques,Adriana;Hornung,RonaldL;Cadavid,Diego
回归热（RF）是一种螺旋体感染，其特征是在高菌血症时出现伴发热的疾病期，与低菌血症时相对健康的无发热期交替出现。流行性RF患者的情况相对较好，循环中的白细胞介素-10（IL-10）水平非常高。我们研究了IL-10在这种感染中起重要保护作用的可能性，使用野生型和IL-10缺陷型小鼠接种RF螺旋体的毒力血清型2。在菌血症高峰期，IL-10的全身产生增加，并在峰后时期迅速消退;相反，IL-6和CXCL 13的产生在峰期增加，但在峰后菌血症期间仍保持升高。IL-10缺乏导致较低的菌血症、增加的特异性抗体产生、更高的CXCL 13和IL-6产生以及影响多个器官的血栓形成和出血并发症伴继发性组织损伤。我们的研究结果表明，IL-10的产生是高度调节RF期间，并发挥了重要的保护作用，在预防出血和血栓性并发症的成本减少病原体控制。
Relapsing fever (RF) is a spirochetal infection characterized by periods of sickness with fever at time of high bacteremia that alternate with afebrile periods of relative well being during low bacteremia. Patients with epidemic RF who are doing relatively well have extraordinarily high levels of interleukin-10 (IL-10) in the circulation. We investigated the possibility that IL-10 plays an important protective role in this infection using wild-type and IL-10-deficient mice inoculated with virulent serotype 2 of the RF spirocheteBorrelia turicatae. During peak bacteremia there was increased systemic production of IL-10 that quickly resolved in the postpeak period; in contrast, IL-6 and CXCL13 production increased during the peak but remained elevated during postpeak bacteremia. IL-10 deficiency resulted in lower bacteremia, increased specific antibody production, higher production of CXCL13 and IL-6, and thrombotic and hemorrhagic complications affecting multiple organs with secondary tissue injury. Our results revealed that production of IL-10 is highly regulated during RF and plays an important protective role in the prevention of hemorrhagic and thrombotic complications at the cost of reduced pathogen control.
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影响因子：
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作者：
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发表时间：
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期刊：
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