The rb pathway and cancer therapeutics.
The rb pathway and cancer therapeutics.
复制标题
DOI：
10.2174/138945009788680392
复制
发表时间：
2009-07
影响因子：
3.2
通讯作者：
Searle JS
中科院分区：
文献类型：
--
作者：
Du W;Searle JS
The retinoblastoma gene, Rb, was originally identified as the tumor suppressor gene mutated in a rare childhood cancer called retinoblastoma (reviewed in. Subsequent studies showed that Rb functions in a pathway that is often functionally inactivated in a large majority of human cancers. Interestingly, recent studies showed that in certain types of cancers, Rb function is actually required for cancer development. The intimate link between the Rb pathway and cancer development suggests that the status of Rb activity can potentially be used to develop targeted therapy. However, a prerequisite will be to understand the role of Rb and its interaction with other signaling pathways in cancer development. In this review, we will discuss the roles of Rb in proliferation, apoptosis and differentiation by reviewing the recent findings in both mammalian systems and different model organisms. In addition, we will discuss strategies that can be employed that specifically target cancer cells based on the status of the Rb pathway.
登录
查看更多内容
影响因子：
64.5
作者：
Du, CY;Fang, M;Wang, XD
通讯作者：
Wang, XD
影响因子：
11.4
作者：
Clavería, C;Caminero, E;Torres, M
通讯作者：
Torres, M
影响因子：
16
作者：
Dick, FA;Dyson, N
通讯作者：
Dyson, N
影响因子：
10.5
作者：
Frolov, MV;Huen, DS;Dyson, NJ
通讯作者：
Dyson, NJ
影响因子：
10.5
作者：
DYNLACHT, BD;FLORES, O;HARLOW, E
通讯作者：
HARLOW, E