Bubble Cloud Behavior and Ablation Capacity for Histotripsy Generated from Intrinsic or Artificial Cavitation Nuclei.
Bubble Cloud Behavior and Ablation Capacity for Histotripsy Generated from Intrinsic or Artificial Cavitation Nuclei.
复制标题
本征或人工空化核产生的组织摩擦学的气泡云行为和消融能力。
DOI：
10.1016/j.ultrasmedbio.2020.10.020
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发表时间：
2021-03
影响因子：
2.9
通讯作者：
Vlaisavljevich E
中科院分区：
文献类型：
--
作者：
Edsall C;Khan ZM;Mancia L;Hall S;Mustafa W;Johnsen E;Klibanov AL;Durmaz YY;Vlaisavljevich E
本研究探讨空化核特征对组织学的影响。高速光学成像比较了由固有空化核和人工空化核（充满气体的微泡和充满液体的纳米锥）产生的组织切片的气泡云行为和消融能力。结果表明，与固有核控制相比，微泡和纳米锥的空化阈值显著降低，在所有情况下都产生了可预测和明确的气泡云。红细胞实验显示本征和纳米锥体幻影完全消融，但微泡幻影仅部分消融。结果还显示，由于气泡膨胀减少（相应的应力和应变降低），人工核影的消融率较低。总的来说，本研究证明了使用人工核降低组织空化阈值的潜力，同时强调了在这些方法的未来发展中需要考虑的气泡云行为和消融能力的差异。
This study examines the effects of cavitation nuclei characteristics on histotripsy. High-speed optical imaging was used to compare bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic and artificial cavitation nuclei (gas-filled microbubbles, fluid-filled nanocones). Results showed a significant decrease in the cavitation threshold for microbubbles and nanocones compared to intrinsic nuclei controls, with predictable and well-defined bubble clouds generated in all cases. Red blood cell experiments showed complete ablations for intrinsic and nanocone phantoms, but only partial ablation in microbubble phantoms. Results also showed a lower rate of ablation in artificial nuclei phantoms due to reduced bubble expansion (and corresponding decreases in stress and strain). Overall, this study demonstrates the potential of using artificial nuclei to reduce the histotripsy cavitation threshold while highlighting differences in the bubble cloud behavior and ablation capacity that need to be considered in the future development of these approaches.
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影响因子：
3.5
作者：
Bader KB;Holland CK
通讯作者：
Holland CK
影响因子：
2.9
作者：
Maxwell, Adam D.;Owens, Gabe;Gurm, Hitinder S.;Ives, Kimberly;Myers, Daniel D., Jr.;Xu, Zhen
通讯作者：
Xu, Zhen
影响因子：
4.9
作者：
Durmaz, Yasemin Yuksel;Vlaisavljevich, Eli;ElSayed, Mohamed
通讯作者：
ElSayed, Mohamed
影响因子：
3.5
作者：
Bader KB;Haworth KJ;Shekhar H;Maxwell AD;Peng T;McPherson DD;Holland CK
通讯作者：
Holland CK
影响因子：
4.9
作者：
Aydin, Omer;Vlaisavljevich, Eli;ElSayed, Mohamed E. H.
通讯作者：
ElSayed, Mohamed E. H.