What we truly know about occupation as a risk factor for ALS: A critical and systematic review
What we truly know about occupation as a risk factor for ALS: A critical and systematic review
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我们对职业作为 ALS 风险因素的真正了解：一项批判性和系统性的回顾
DOI：
10.3109/17482960802430799
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发表时间：
2009
影响因子：
--
通讯作者：
L. H. van den Berg
中科院分区：
文献类型：
--
作者：
N. Sutedja;K. Fischer;J. Veldink;G. J. van der Heijden;H. Kromhout;D. Heederik;M. Huisman;J. Wokke;L. H. van den Berg
职业和环境暴露可能导致散发性肌萎缩性侧索硬化症（ALS）的发生。为了总结现有证据，根据MOOSE指南对职业作为ALS潜在决定因素的文献进行了系统回顾。从MEDLINE、EMBASE、CINAHL和Cochrane数据库中，根据Armon的ALS危险因素研究分类系统对选定的研究进行方法学评价。所研究的每个职业都按照国际标准职业分类（ISCO-88）重新分类。采用点票法对数据进行汇总。在3773项可能相关的研究中，51项最初被纳入。其中，12项研究提供了个体职业的风险评估——1项病例对照研究，2项基于登记的病例对照研究，9项基于登记的队列研究。所有的研究都属于阿蒙的证据等级IV类，这表明了方法学的局限性。由于研究方法的异质性，数据不能汇总。计票方法显示了几个候选职业：兽医和其他卫生工作者、运动员、美发师、发电厂、电力和军事工作者。然而，需要设计良好的研究，对职业进行标准化评估，以提供关于ALS外源性危险因素的更明确的答案。
Occupational and environmental exposures may contribute to the risk of developing sporadic amyotrophic lateral sclerosis (ALS). To summarize the available evidence, a systematic review of the literature on occupation as a potential determinant of ALS was performed according to the MOOSE guidelines. From MEDLINE, EMBASE, CINAHL, and Cochrane databases, selected studies were methodologically appraised according to Armon's classification system for ALS risk factor studies. Each occupation studied was reclassified according to the International Standard Classification of Occupations (ISCO-88). The vote-counting method was applied to summarize the data. Of 3773 potentially relevant studies, 51 were initially included. Of these, 12 studies provided risk estimates for individual occupations – one case-control, two register-based case-control, and nine register-based cohort studies. All studies fell into Armon's level of evidence class IV, indicating methodological limitations. Due to the heterogeneity of study methodology, data could not be pooled. The vote-counting method revealed several candidate occupations: veterinarians and other health workers, athletes, hairdressers, power-production plant, electrical and military workers. However, well designed studies with standardized assessment of occupation are needed to provide a more definitive answer about exogenous risk factors of ALS.
影响因子：
3.5
作者：
Park, RM;Schulte, PA;Dosemeci, M
通讯作者：
Dosemeci, M