Balancing Inflammation and Central Nervous System Homeostasis: T Cell Receptor Signaling in Antiviral Brain T(RM) Formation and Function.
Balancing Inflammation and Central Nervous System Homeostasis: T Cell Receptor Signaling in Antiviral Brain T(RM) Formation and Function.
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DOI：
10.3389/fimmu.2020.624144
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发表时间：
2020
影响因子：
7.3
通讯作者：
Lukacher AE
中科院分区：
文献类型：
--
作者：
Netherby-Winslow CS;Ayers KN;Lukacher AE
组织驻留记忆 (TRM) CD8 T 细胞提供针对区域病原体再次遭遇的早期前线防御。 CD8 TRM 主要驻留在非淋巴组织中并且不循环。除了这种解剖学差异之外，TRM 在转录和表型上也与中央记忆 T 细胞 (TCM) 和效应记忆 T 细胞 (TEM) 不同。此外，TRM在屏障组织（例如胃肠道、呼吸道、泌尿生殖道和皮肤）和非屏障器官（例如脑、肝脏、肾脏）中的表型、功能和转录上都存在差异。在大脑中，TRM 受到平衡 TRM 激活和重要有丝分裂后神经元保存的环境环境的控制。促进大脑 TRM 发展和维持的因素（其中 T 细胞受体 (TCR) 信号强度和持续时间是核心决定因素）取决于传染源以及平息潜在致病性炎症的抑制性标记物对 TCR 信号的调节。本综述将探讨我们目前对驱动大脑 (b)TRM 表型和功能获得的背景相关因素的理解，并讨论 TRM 在维持组织稳态的同时促进原位保护性免疫反应的贡献。
Tissue-resident memory (TRM) CD8 T cells provide early frontline defense against regional pathogen reencounter. CD8 TRM are predominantly parked in nonlymphoid tissues and do not circulate. In addition to this anatomic difference, TRM are transcriptionally and phenotypically distinct from central-memory T cells (TCM) and effector-memory T cells (TEM). Moreover, TRM differ phenotypically, functionally, and transcriptionally across barrier tissues (e.g., gastrointestinal tract, respiratory tract, urogenital tract, and skin) and in non-barrier organs (e.g., brain, liver, kidney). In the brain, TRM are governed by a contextual milieu that balances TRM activation and preservation of essential post-mitotic neurons. Factors contributing to the development and maintenance of brain TRM, of which T cell receptor (TCR) signal strength and duration is a central determinant, vary depending on the infectious agent and modulation of TCR signaling by inhibitory markers that quell potentially pathogenic inflammation. This review will explore our current understanding of the context-dependent factors that drive the acquisition of brain (b)TRM phenotype and function, and discuss the contribution of TRM to promoting protective immune responses in situ while maintaining tissue homeostasis.
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DOI：
10.1084/jem.20021910
发表时间：
2003-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Curtsinger JM;Lins DC;Mescher MF
通讯作者：
Mescher MF
影响因子：
7.3
作者：
Daniels MA;Teixeiro E
通讯作者：
Teixeiro E
影响因子：
7.3
作者：
Corgnac S;Boutet M;Kfoury M;Naltet C;Mami-Chouaib F
通讯作者：
Mami-Chouaib F
影响因子：
4.4
作者：
Boldison, Joanne;Chu, Colin J.;Nicholson, Lindsay B.
通讯作者：
Nicholson, Lindsay B.
影响因子：
82.9
作者：
Gaide O;Emerson RO;Jiang X;Gulati N;Nizza S;Desmarais C;Robins H;Krueger JG;Clark RA;Kupper TS
通讯作者：
Kupper TS