High-pressure ion mobility spectrometry.
High-pressure ion mobility spectrometry.
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DOI：
10.1021/ac802431q
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发表时间：
2009-05-01
影响因子：
7.4
通讯作者：
Hill, Herbert H.
中科院分区：
文献类型：
--
作者：
Davis, Eric J.;Dwivedi, Prabha;Tam, Maggie;Siems, William F.;Hill, Herbert H.
利用小型独立离子迁移谱仪(IMS)研究了环境压力对离子迁移率、分辨率和离子电流的影响。这项工作展示了第一个在常压以上的离子迁移率光谱的例子。给出了化学战剂(CWA)、刺激剂甲基膦酸二甲酯(DMMP)和其他几种标准化合物在超常压条件下的离子迁移率光谱。IMS在700至4560托的压力下运行。根据标准IMS理论预测，在特定电压下获得了作为压力的函数的最佳分辨率，并且在较高电压下获得了较高的最佳分辨率。然而，在高压下，分辨率并没有像理论预测的那样增加，这可能是由于离子聚集。然而，压力的增加被发现提高了IMS的分辨率。高压提高分辨率的一个例子是分离环己胺(K0=1.83)和2-己酮(K0=1.86)(其中K0是折合的迁移率值)。这两种化合物的产物离子在常压下不能分离，但当缓冲气体压力升高到2280Torr时，可以接近基线分离。在从环境到4560Torr的压力下，也检查了总离子电流。当用压力研究时，发现总离子电流达到最大值，最初随着压力的增加而增加。
The effects of above-ambient pressure on ion mobility on resolving power, resolution, and ion current were investigated using a small, stand-alone ion mobility spectrometer (IMS). This work demonstrates the first example of ion mobility spectrometry at pressures above ambient. Ion mobility spectra of chemical warfare agent (CWA) stimulant dimethyl methylphosphonate (DMMP) and several other standard compounds are shown for superambient conditions. The IMS was operated at pressures from 700 to 4560 Torr. An optimal resolving power was obtained at a specific voltage as a function of pressure, with higher optimal resolving powers obtained at higher voltages, as predicted from standard IMS theory. At high pressures, however, resolving power did not increase as much as theory predicted, presumably due to ion clustering. Nevertheless, an increase in pressure was found to improve resolution in IMS. One example where high pressure improved resolution was the separation of cyclohexylamine (K0 = 1.83) and 2-hexanone (K0 = 1.86) (where K0 is the reduced mobility value). The product ions of these two compounds could not be separated at ambient pressure but could be nearly baseline separated when the pressure of the buffer gas was raised to 2280 Torr. Total ion current was also examined at pressures from ambient up to 4560 Torr. Total ion current, when investigated with pressure, was found to reach a maximum, initially rising with increased pressure.
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影响因子：
7.4
作者：
Nazarov, Erkinjon G.;Coy, Stephen L.;Eiceman, Gary A.
通讯作者：
Eiceman, Gary A.
影响因子：
7.4
作者：
SIEMS, WF;WU, C;MCMINN, DG
通讯作者：
MCMINN, DG
DOI：
10.1016/j.jasms.2007.04.007
发表时间：
2007-07-01
影响因子：
3.2
作者：
Dwivedi, Prabha;Bendiak, Brad;Hill, Herbert H., Jr.
通讯作者：
Hill, Herbert H., Jr.
影响因子：
--
作者：
Kanu, Abu B.;Hill, Herbert H., Jr.;Walters, Robert N.
通讯作者：
Walters, Robert N.
影响因子：
7.4
作者：
Cao, LB;Harrington, PD;Liu, C
通讯作者：
Liu, C