Role of polycomb proteins in regulating HSV-1 latency.

Role of polycomb proteins in regulating HSV-1 latency.
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DOI:
10.3390/v5071740
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发表时间:
2013-07-15
期刊:
Viruses
影响因子:
--
通讯作者:
Bloom D
Bloom D
中科院分区:
其他
文献类型:
--
作者:
Watson Z;Dhummakupt A;Messer H;Phelan D;Bloom D

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Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition.
HSV-1高效再活化株中LAT和ICP4上的外染色质在再活化后的变化更为普遍
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