B Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for T(H)17 Differentiation.
B Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for T(H)17 Differentiation.
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DOI：
10.3389/fimmu.2021.698849
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发表时间：
2021
影响因子：
7.3
通讯作者：
Jungnickel B
中科院分区：
文献类型：
--
作者：
Ferreira-Gomes M;Wich M;Böde S;Hube B;Jacobsen ID;Jungnickel B
白色念珠菌通常是人类肠道菌群的良性成员，但在某些情况下，例如在免疫功能低下的宿主中，可能会变得致病性。先天免疫系统，特别是中性粒细胞和巨噬细胞，构成了抵御真菌入侵的关键第一道防线，然而适应性免疫可能提供长期保护，从而允许高危患者接种疫苗。虽然TH1和TH17细胞对抗真菌反应很重要，但B细胞和抗体在防止白色念珠菌感染中的作用尚不明确。在这项研究中，我们发现白色念珠菌菌丝而不是酵母，以及真菌细胞壁成分通过Toll样受体2触发的MyD88信号直接激活B细胞，导致IgG1的产生增加。在该系统中，B细胞的激活缺少Dectin-1信号和B细胞受体的特异性识别，而TLR2/MyD88信号与CD40信号协同促进B细胞的激活。重要的是，通过MyD88信号对白色念珠菌的识别也是诱导B细胞分泌IL-6的必要条件，这在T-B细胞共培养实验中促进了TH17的极化。因此，B细胞可能直接被侵袭性白色念珠菌激活，从而产生抗体和T细胞，帮助清除真菌。
Candida albicans is usually a benign member of the human gut microbiota, but can become pathogenic under certain circumstances, for example in an immunocompromised host. The innate immune system, in particular neutrophils and macrophages, constitutes a crucial first line of defense against fungal invasion, however adaptive immunity may provide long term protection and thus allow vaccination of at risk patients. While TH1 and TH17 cells are important for antifungal responses, the role of B cells and antibodies in protection from C. albicans infection is less well defined. In this study, we show that C. albicans hyphae but not yeast, as well as fungal cell wall components, directly activate B cells via MyD88 signaling triggered by Toll- like receptor 2, leading to increased IgG1 production. While Dectin-1 signals and specific recognition by the B cell receptor are dispensable for B cell activation in this system, TLR2/MyD88 signals cooperate with CD40 signals in promoting B cell activation. Importantly, recognition of C. albicans via MyD88 signaling is also essential for induction of IL-6 secretion by B cells, which promotes TH17 polarization in T-B cell coculture experiments. B cells may thus be activated directly by C. albicans in its invasive form, leading to production of antibodies and T cell help for fungal clearance.
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影响因子：
3.7
作者：
Jain S;Chodisetti SB;Agrewala JN
通讯作者：
Agrewala JN
Dectin-1介导β-葡聚糖的生物学作用。
DOI：
10.1084/jem.20021890
发表时间：
2003-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brown GD;Herre J;Williams DL;Willment JA;Marshall AS;Gordon S
通讯作者：
Gordon S
影响因子：
6
作者：
Seo BS;Lee SH;Lee JE;Yoo YC;Lee J;Park SR
通讯作者：
Park SR
影响因子：
30.5
作者：
Gringhuis, Sonja I.;den Dunnen, Jeroen;Geijtenbeek, Teunis B. H.
通讯作者：
Geijtenbeek, Teunis B. H.
影响因子：
4.8
作者：
Lowman, Douglas W.;Greene, Rachel R.;Williams, David L.
通讯作者：
Williams, David L.