Weight loss increases follicle stimulating hormone in overweight postmenopausal women [corrected].
Weight loss increases follicle stimulating hormone in overweight postmenopausal women [corrected].
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DOI：
10.1002/oby.20917
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发表时间：
2015-01
期刊：
影响因子：
6.9
通讯作者：
Barrett-Connor, Elizabeth
中科院分区：
文献类型：
--
作者：
Kim, Catherine;Randolph, John F.;Golden, Sherita H.;Labrie, Fernand;Kong, Shengchun;Nan, Bin;Barrett-Connor, Elizabeth
To examine the impact of a weight loss intervention upon follicle stimulating hormone (FSH) levels in postmenopause. Participants were postmenopausal, overweight, glucose-intolerant women not using exogenous estrogen (n=382) in the Diabetes Prevention Program. Women were randomized to intensive lifestyle change (ILS) with the goals of weight reduction of at least 7% of initial weight and 150 minutes per week of moderate intensity exercise, metformin 850 mg, or placebo administered twice a day. Randomization to ILS led to small increases in FSH between baseline and 1-year follow-up vs. placebo (2.3 IU/l vs. -0.81 IU/l, p<0.01). Increases in FSH were correlated with decreases in weight (r=-0.165, p<0.01) and E2 (r=-0.464, p<0.0001) after adjustment for age, race/ethnicity, and randomization arm. Changes in FSH were still significantly associated with changes in weight even after adjustment for E2 levels. Metformin users had reductions in weight but non-significant changes in FSH and E2 levels vs. placebo. Weight loss leads to small increases in FSH among overweight, postmenopausal women, potentially through pathways mediated by endogenous estrogen as well as other pathways.
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
6.7
作者：
Pasquali, Renato
通讯作者：
Pasquali, Renato
影响因子：
4.9
作者：
Sowers, MaryFran R.;Wildman, Rachel P.;Jannausch, Mary L.
通讯作者：
Jannausch, Mary L.
影响因子：
11.2
作者：
McTiernan, A;Tworoger, SS;Schwartz, RS
通讯作者：
Schwartz, RS
影响因子：
8.2
作者：
Ding, E. L.;Song, Y.;Liu, S.
通讯作者：
Liu, S.