Histological Evidence for the Enteric Nervous System and the Choroid Plexus as Alternative Routes of Neuroinvasion by SARS-CoV2.
Histological Evidence for the Enteric Nervous System and the Choroid Plexus as Alternative Routes of Neuroinvasion by SARS-CoV2.
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DOI：
10.3389/fnana.2020.596439
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发表时间：
2020
影响因子：
2.9
通讯作者：
Neckel PH
中科院分区：
文献类型：
--
作者：
Deffner F;Scharr M;Klingenstein S;Klingenstein M;Milazzo A;Scherer S;Wagner A;Hirt B;Mack AF;Neckel PH
越来越多的证据表明，新型冠状病毒SARS-CoV 2在COVID-19患者的一个亚组中引起神经系统症状。虽然已经提出了大量的神经侵袭途径的理论，但很少有组织学证据支持这些假设。因此，我们对ACE 2和TMPRSS 2进行了免疫染色，这两种蛋白酶对SARS-CoV 2进入宿主细胞至关重要，在人类肠神经系统（ENS）以及侧脑室的脉络丛中。这两个部位都很重要，但往往被忽视的神经系统入口。我们发现ACE 2和TMPRSS 2由小肠和大肠的肠神经元和神经胶质细胞以及脉络丛上皮细胞表达，表明这些细胞满足病毒进入的分子要求。总之，我们的研究结果是基本的组织学证据，证实了目前的理论，神经入侵的SARS冠状病毒2。
Evidence is mounting that the novel corona virus SARS-CoV2 inflicts neurological symptoms in a subgroup of COVID-19 patients. While plenty of theories on the route of neuroinvasion have been proposed, little histological evidence has been presented supporting any of these hypotheses. Therefore, we carried out immunostainings for ACE2 and TMPRSS2, two proteinases crucial for the entry of SARS-CoV2 into host cells, in the human enteric nervous system (ENS), as well as in the choroid plexus of the lateral ventricles. Both of these sites are important, yet often neglected entry gates to the nervous system. We found that ACE2 and TMPRSS2 are expressed by enteric neurons and glial cells of the small and large intestine, as well as choroid plexus epithelial cells, indicating that these cells meet the molecular requirements for viral entry. Together, our results are fundamental histological evidence substantiating current theories of neuroinvasion by SARS-CoV2.
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DOI：
10.1007/s42451-020-00191-9
发表时间：
2020-05-11
期刊：
DGNeurologie
影响因子：
--
作者：
Bösel J;Berlit P
通讯作者：
Berlit P
影响因子：
7.3
作者：
Hamming, I;Timens, W;van Goor, H
通讯作者：
van Goor, H
影响因子：
30.3
作者：
Khoury-Hanold W;Yordy B;Kong P;Kong Y;Ge W;Szigeti-Buck K;Ralevski A;Horvath TL;Iwasaki A
通讯作者：
Iwasaki A
影响因子：
5
作者：
Bilinska, Katarzyna;Jakubowska, Patrycja;Butowt, Rafal
通讯作者：
Butowt, Rafal
影响因子：
3.3
作者：
Morais da Silveira, Alexandre Barcelos;de Oliveira, Enio C.;Brehmer, Axel
通讯作者：
Brehmer, Axel