Exposure to traffic: lung function and health status in adults with asthma.
Exposure to traffic: lung function and health status in adults with asthma.
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DOI：
10.1016/j.jaci.2008.10.062
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发表时间：
2009-03
影响因子：
14.2
通讯作者：
Blanc, Paul D.
中科院分区：
文献类型：
--
作者：
Balmes, John R.;Earnest, Gillian;Katz, Patricia P.;Yelin, Edward H.;Eisner, Mark D.;Chen, Hubert;Trupin, Laura;Lurmann, Fred;Blanc, Paul D.
暴露于交通与儿童哮喘的结果有关，但其对成人哮喘的影响尚未得到充分研究。检验肺功能和健康状况与交通暴露相关的假设。我们测量了一组患有哮喘或鼻炎的成年人（n=176; 145例哮喘患者）的1秒用力呼气量（FEV 1）%预测值、使用简明身体健康量表（SF-12 PCS）的一般健康状况和使用Marks哮喘生活质量问卷的生活质量（QoL）。我们通过对受试者的居住地址进行地理编码并分配到道路的距离来评估交通暴露。使用线性回归研究了到最近巷道的距离和到最近主要巷道的距离与FEV1%预测值或SF-12 PCS之间的关系。FEV1%预测值与最近道路（p=0.01）和主要道路（p=0.02）的距离呈正相关。SF-12 PCS和QoL与任一交通变量均无显著相关性。调整收入、吸烟和肥胖并没有实质性改变交通变量与FEV1%预测值的相关性（最近的道路p=0.04，最近的主要道路p=0.02），也没有导致与SF-12 PCS或OoL的相关性变得显著。交通暴露与哮喘成人肺功能下降相关。
Exposure to traffic has been associated with asthma outcomes in children, but its effect on asthma in adults has not been well studied. To test the hypothesis that lung function and health status are associated with traffic exposures. We measured forced expiratory volume in 1 second (FEV1) % predicted, general health status using the Physical Component Scale of the Short Form (SF-12 PCS) and quality of life (QoL) using the Marks Asthma Quality of Life questionnaire in a cohort of adults with asthma or rhinitis (n=176; 145 with asthma). We assessed exposures to traffic by geo-coding subjects’ residential addresses and assigning distance to roadways. Associations between distance to nearest roadway and distance to nearest major roadway and FEV1 % predicted or SF-12 PCS were studied using linear regression. FEV1 % predicted was positively associated with distance from nearest roadway (p=0.01) and major roadway (p=0.02). SF-12 PCS and QoL were not significantly associated with either traffic variable. Adjustment for income, smoking, and obesity did not substantively change the associations of the traffic variables with FEV1 % predicted (p=0.04 for nearest roadway and p=0.02 for nearest major roadway) and did not cause associations with either SF-12 PCS or OoL to become significant Traffic exposure was associated with decreased lung function in adults with asthma.
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影响因子：
24.3
作者：
Larsson, B-M.;Sehlstedt, M.;Svartengren, M.
通讯作者：
Svartengren, M.
影响因子：
6.3
作者：
Morris, SE;Sale, RC;Boucher, BJ
通讯作者：
Boucher, BJ
影响因子：
9.6
作者：
Blanc, PD;Cisternas, M;Yelin, EH
通讯作者：
Yelin, EH
影响因子：
10
作者：
Eisner, MD;Yelin, EH;Blanc, PD
通讯作者：
Blanc, PD
影响因子：
7.2
作者：
Blanc, PD;Trupin, L;Yelin, EH
通讯作者：
Yelin, EH