The role of leukocytes in ischemic damage, reperfusion injury and repair of the myocardium
The role of leukocytes in ischemic damage, reperfusion injury and repair of the myocardium
复制标题
白细胞在心肌缺血损伤、再灌注损伤和修复中的作用
DOI：
--
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
C. Wayne Smith
中科院分区：
文献类型：
--
作者：
K M Mullane;C. Wayne Smith
Chirac 于 1698 年首次描述了狗对冠状动脉闭塞的反应 [2]，从而在临床上认识到心肌梗塞之前。尽管人们承认，只有在彻底了解病变如何发展和消退以及这些过程发生的速度的基础上，才能明智、科学地治疗任何病理过程[3]，但近300年后，人们对确定心肌损伤最终程度所涉及的过程和事件仍然知之甚少。然而，急性心肌梗死的组织学变化发展相对缓慢[4]，并且已被广泛记录（参见参考文献[5-7]进行综述）。此外，由于缺血性心脏病是西方世界过早发病和死亡的主要原因，因此对肌细胞坏死的发病机制以及各种不同干预措施对其的影响进行了大量研究，Braunwald [8] 得出结论：
“仅仅因为心肌组织位于最近闭塞的冠状动脉的分布范围内，并不意味着它必然会导致细胞死亡。”
The response to occlusion of a coronary artery in dogs was first described by Chirac in 1698 [2], thereby preceding the clinical recognition of myocardial infarction. Although it is acknowledged that the treatment of any pathologic process can be carried out intelligently and scientifically only when it is based on a thorough understanding of how the lesion develops and resolves, and the speed with which these processes occur [3], almost 300 years later the process and events involved in defining the ultimate extent of myocardial injury remain poorly understood. Yet the histologic changes in acute myocardial infarction develop relatively slowly [4], and have been documented extensively (see references [5–7] for review). Moreover, as ischemic heart disease is a major cause of premature morbidity and mortality in the western world, there have been a multitude of studies on the pathogenesis of myocellular necrosis and how it can be influenced by a variety of different interventions, leading Braunwald [8] to conclude,
“Just because myocardial tissue lies within the distribution of a recently occluded coronary artery, does not mean that it is necessarily condemned to cell death.”
登录
查看更多内容
影响因子：
37.8
作者：
HAMMERMAN, H;KLONER, RA;BRAUNWALD, E
通讯作者：
BRAUNWALD, E
影响因子：
15.9
作者：
GIMBRONE, MA;BROCK, AF;SCHAFER, AI
通讯作者：
SCHAFER, AI
影响因子：
--
作者：
HERNANDEZ, LA;GRISHAM, MB;GRANGER, DN
通讯作者：
GRANGER, DN
BW755C 在缺血性心肌损伤的闭塞再灌注模型中的作用。
影响因子：
4.8
作者：
Jolly,SR;Lucchesi,BR
通讯作者：
Lucchesi,BR
影响因子：
4.4
作者：
D. Anderson;L. Miller;F. Schmalstieg;R. Rothlein;T. Springer
通讯作者：
D. Anderson;L. Miller;F. Schmalstieg;R. Rothlein;T. Springer