Insights into the trimeric HIV-1 envelope glycoprotein structure.
Insights into the trimeric HIV-1 envelope glycoprotein structure.
复制标题
对三聚体HIV-1包膜糖蛋白结构的见解。
DOI：
10.1016/j.tibs.2014.12.006
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发表时间：
2015-02
影响因子：
13.8
通讯作者：
Wilson, Ian A.
中科院分区：
文献类型：
--
作者：
Ward, Andrew B.;Wilson, Ian A.
HIV-1包膜糖蛋白（Env）三聚体负责受体识别和与CD 4 + T细胞的病毒融合，并且是中和抗体的唯一靶标。因此，了解它的分子结构具有重要意义。然而，Env三聚体已被证明是3D结构测定的具有挑战性的目标。最近的EM和X射线结构终于使我们能够理解Env三聚体的结构复杂性和独特特征，以及它如何被不断扩大的强效广泛中和抗体库识别。在这里，我们描述了我们目前的知识的Env三聚体结构的背景下，令人兴奋的最新进展，在识别和表征艾滋病毒广泛中和抗体。
The HIV-1 envelope glycoprotein (Env) trimer is responsible for receptor recognition and viral fusion with CD4+ T cells and is the sole target for neutralizing antibodies. Thus, understanding its molecular architecture is of significant interest. However, the Env trimer has proved to be a challenging target for 3D structure determination. Recent EM and X-ray structures have at last enabled us to appreciate the structural complexity and unique features of the Env trimer, and how it is recognized by an ever-expanding arsenal of potent broadly neutralizing antibodies. Here we describe our current knowledge of the Env trimer structure in the context of the exciting recent developments in identification and characterization of HIV broadly neutralizing antibodies.
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通讯作者：
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