Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers.
Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers.
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DOI：
10.1016/j.immuni.2014.04.009
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发表时间：
2014-05-15
期刊：
影响因子：
32.4
通讯作者：
Burton, Dennis R.
中科院分区：
文献类型：
--
作者：
Falkowska, Emilia;Le, Khoa M.;Ramos, Alejandra;Doores, Katie J.;Lee, Jeong Hyun;Blattner, Claudia;Ramirez, Alejandro;Derking, Ronald;van Gils, Marit J.;Liang, Chi-Hui;Mcbride, Ryan;von Bredow, Benjamin;Shivatare, Sachin S.;Wu, Chung-Yi;Chan-Hui, Po-Ying;Liu, Yan;Feizi, Ten;Zwick, Michael B.;Koff, Wayne C.;Seaman, Michael S.;Swiderek, Kristine;Moore, John P.;Evans, David;Paulson, James C.;Wong, Chi-Huey;Ward, Andrew B.;Wilson, Ian A.;Sanders, Rogier W.;Poignard, Pascal;Burton, Dennis R.
广泛中和的艾滋病毒抗体非常受欢迎(a)作为模板指导疫苗设计，并告知候选疫苗的真实性，(b)协助进行结构研究，(c)作为潜在的治疗方法。然而，这些抗体在病毒包膜突刺上的靶标数量是有限的。在这里，我们描述了一组人类单克隆抗体，它们定义了HIV Env上以前未定义的靶标。这些抗体识别gp41预融合构象上的甘聚糖依赖性表位，并明确区分裂解的和未裂解的Env三聚体，这是一个重要的特性，因为越来越多的证据表明，为了模仿功能性HIV包膜刺突，候选疫苗需要裂解。这组抗体的可用性扩大了艾滋病毒疫苗靶点的数量，并提供了表征天然包膜尖峰的试剂。
Broadly neutralizing antibodies to HIV are much sought-after (a) to guide vaccine design, both as templates and to inform on the authenticity of vaccine candidates, (b) to assist in structural studies and (c) as potential therapeutics. However, the number of targets on the viral envelope spike for such antibodies is limited. Here, we describe a set of human monoclonal antibodies that define a previously undefined target on HIV Env. The antibodies recognize a glycan-dependent epitope on the prefusion conformation of gp41 and unambiguously distinguish cleaved from uncleaved Env trimers, an important property given increasing evidence that cleavage is required for vaccine candidates that seek to mimic the functional HIV envelope spike. The availability of this set of antibodies expands the number of vaccine targets on HIV and provides reagents to characterize the native envelope spike.
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影响因子：
16.8
作者：
Kong, Leopold;Lee, Jeong Hyun;Doores, Katie J.;Murin, Charles D.;Julien, Jean-Philippe;McBride, Ryan;Liu, Yan;Marozsan, Andre;Cupo, Albert;Klasse, Per-Johan;Hoffenberg, Simon;Caulfield, Michael;King, C. Richter;Hua, Yuanzi;Le, Khoa M.;Khayat, Reza;Deller, Marc C.;Clayton, Thomas;Tien, Henry;Feizi, Ten;Sanders, Rogier W.;Paulson, James C.;Moore, John P.;Stanfield, Robyn L.;Burton, Dennis R.;Ward, Andrew B.;Wilson, Ian A.
通讯作者：
Wilson, Ian A.
影响因子：
64.8
作者：
Huang J;Ofek G;Laub L;Louder MK;Doria-Rose NA;Longo NS;Imamichi H;Bailer RT;Chakrabarti B;Sharma SK;Alam SM;Wang T;Yang Y;Zhang B;Migueles SA;Wyatt R;Haynes BF;Kwong PD;Mascola JR;Connors M
通讯作者：
Connors M
影响因子：
3.7
作者：
Ferguson AL;Falkowska E;Walker LM;Seaman MS;Burton DR;Chakraborty AK
通讯作者：
Chakraborty AK
DOI：
10.1084/jem.20120423
发表时间：
2012-07-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Klein F;Gaebler C;Mouquet H;Sather DN;Lehmann C;Scheid JF;Kraft Z;Liu Y;Pietzsch J;Hurley A;Poignard P;Feizi T;Morris L;Walker BD;Fätkenheuer G;Seaman MS;Stamatatos L;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
4.4
作者：
Go, Eden P.;Chang, Qing;Liao, Hua-Xin;Sutherland, Laura L.;Alam, S. Munir;Haynes, Barton F.;Desaire, Heather
通讯作者：
Desaire, Heather