Circadian clock control of endocrine factors.
Circadian clock control of endocrine factors.
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DOI：
10.1038/nrendo.2014.78
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发表时间：
2014-08
期刊：
影响因子：
--
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文献类型：
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生物体在一天中会经历需求/压力的剧烈波动。为了将生物过程维持在生理范围内，必须进化出预测和适应这些日常波动的机制。内分泌因素无疑在体内平衡中发挥着不可或缺的作用。不仅各种内分泌因子的循环水平在 24 个周期内波动，而且靶组织对这些信号/刺激的反应也会波动。新出现的证据表明，这些日常波动并不仅仅是由于与睡眠/觉醒和进食/禁食周期相关的行为波动而发生，而是部分由称为生物钟的内在计时机制精心策划的。通过遗传和/或环境手段破坏生物钟似乎会引发许多常见疾病，包括心脏代谢疾病和癌症。总的来说，本文综述的这些观察结果表明，旨在重新调整正常昼夜节律的策略具有治疗各种内分泌相关疾病的潜力。
Organisms experience dramatic fluctuations in demands/stresses over the course of the day. In order to maintain biological processes within physiologic boundaries, it is imperative that mechanisms have evolved for anticipation of, and adaptation to, these daily fluctuations. Endocrine factors undoubtedly play an integral role in homeostasis. Not only do circulating levels of various endocrine factors oscillate over the 24 period, but so too does responsiveness of target tissues to these signals/stimuli. Emerging evidence suggests that these daily oscillations do not occur solely in response to behavioral fluctuations associated with sleep/wake and feeding/fasting cycles, but are orchestrated in part by an intrinsic timekeeping mechanism known as the circadian clock. Disruption of circadian clocks, through genetic and/or environmental means, appears to precipitate numerous common disorders, including cardiometabolic diseases and cancer. Collectively, these observations, which are reviewed within the current article, have led to suggestion that strategies designed to realign normal circadian rhythmicities hold a therapeutic potential for the treatment of various endocrine-related disorders.
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影响因子：
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