Psychometric and genetic architecture of substance use disorder and behavioral disinhibition measures for gene association studies.
Psychometric and genetic architecture of substance use disorder and behavioral disinhibition measures for gene association studies.
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DOI：
10.1007/s10519-010-9417-2
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发表时间：
2011-07
影响因子：
2.6
通讯作者：
McGue, Matt
中科院分区：
文献类型：
--
作者：
Hicks, Brian M.;Schalet, Benjamin D.;Malone, Stephen M.;Iacono, William G.;McGue, Matt
关键词：
使用大双胞胎，家庭，并通过在明尼苏达州中心进行的研究双胞胎和家庭研究，我们描述了我们的努力，以制定措施的物质使用障碍（SUD）相关的表型的目标，在全基因组关联分析。从一组不同的相对狭窄的方面水平的措施，我们确定了5个结构的中间复杂性：尼古丁，酒精消费，酒精依赖，非法药物和行为去抑制。5个结构中度相关（平均r = 0.57），反映了物质滥用和反社会行为的一般外化责任。对双胞胎和收养数据的分析显示，这种一般的外部化责任占了每个中间水平结构中大部分遗传风险的比例，尽管每个结构也表现出显著的独特遗传和环境风险。进一步的分析显示，年龄和性别的重大影响，显着的共享环境的影响，这些共享的环境影响的机制，通过兄弟姐妹，而不是父母。我们的研究结果为全基因组关联分析提供了基础，以检测SUD的风险等位基因以及对SUD的新见解。
Using large twin, family, and adoption studies conducted at the Minnesota Center for Twin and Family Research, we describe our efforts to develop measures of substance use disorder (SUD) related phenotypes for targets in genome wide association analyses. Beginning with a diverse set of relatively narrow facet-level measures, we identified 5 constructs of intermediate complexity: nicotine, alcohol consumption, alcohol dependence, illicit drug, and behavioral disinhibition. The 5 constructs were moderately correlated (mean r = .57) reflecting a general externalizing liability to substance abuse and antisocial behavior. Analyses of the twin and adoption data revealed that this general externalizing liability accounted for much of the genetic risk in each of the intermediate-level constructs, though each also exhibited significant unique genetic and environmental risk. Additional analyses revealed substantial effects for age and sex, significant shared environmental effects, and that the mechanism of these shared environmental effects operates via siblings rather than parents. Our results provide a foundation for genome wide association analyses to detect risk alleles for SUDs as well as novel insights into SUDs.
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影响因子：
10.6
作者：
Grant, Julia D.;Agrawal, Arpana;Bucholz, Kathleen K.;Madden, Pamela A. F.;Pergadia, Michele L.;Nelson, Elliot C.;Lynskey, Michael T.;Todd, Richard D.;Todorov, Alexandre A.;Hansell, Narelle K.;Whitfield, John B.;Martin, Nicholas G.;Heath, Andrew C.
通讯作者：
Heath, Andrew C.
影响因子：
6
作者：
Dick, Danielle M.;Agrawal, Arpana;Bierut, Laura J.
通讯作者：
Bierut, Laura J.
影响因子：
--
作者：
Dick, Danielle M.;Aliev, Fazil;Goate, Alison
通讯作者：
Goate, Alison
影响因子：
2.6
作者：
Gilmore, Casey S.;Malone, Stephen M.;Iacono, William G.
通讯作者：
Iacono, William G.
DOI：
10.1375/1369052022983
发表时间：
2002-04-01
期刊：
TWIN RESEARCH
影响因子：
--
作者：
Heath, AC;Martin, NG;Madden, PAF
通讯作者：
Madden, PAF